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MetabolomicsFSCN1 as a new druggable target in adrenocortical carcinoma

Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with a high risk of relapse and metastatisation. The actin-bundling protein fascin (FSCN1) is overexpressed in aggressive ACC and represents a reliable prognostic indicator. FSCN1 has been shown to synergize with the Rho/Rac GEF VAV2 i...

2023-03-20 | MTBLS6402 | MetaboLights
TranscriptomicsGene exrpression profiling of childhood adrenocortical tumors
Pediatric adrenocortical tumors (ACT) are rare and often fatal malignancies; little is known regarding their etiology and biology. To provide additional insight into the nature of ACT, we determined the gene expression profiles of 24 pediatric tumors (five adenomas, 18 carcinomas, and one undetermin...
ORGANISM(S): Homo sapiens 
2015-11-25 | E-GEOD-75415 | biostudies-arrayexpress
TranscriptomicsAdrenocortical Carcinoma Gene Expression Profiling [Agilent]
Adrenocortical carcinoma (ACC) is an aggressive endocrine tumor with a poor 5 year survival rate of 10-20%. We used expression profiling to assess the transcriptional changes associated with ACC as compared to normal adrenal glands with the goal of identifying new targets for treatment. Fourteen A...
ORGANISM(S): Homo sapiens 
2013-11-21 | E-GEOD-19775 | biostudies-arrayexpress
TranscriptomicsStudy of miRNA expression in childhood adrenocortical tumors
We studied the miRNA expression profile of a series of childhood adrenocortical tumors (ACT) and age-matched normal adrenal samples 25 ACT - 5 normal
ORGANISM(S): Homo sapiens 
2010-04-01 | E-GEOD-19856 | biostudies-arrayexpress
TranscriptomicsCharacterization of differential gene expression in adrenocortical tumors harbouring β-catenin (CTNNB1) mutations.
Mutations of β-catenin gene (CTNNB1) are frequent in adrenocortical adenomas (AA) and carcinomas (ACC). However, the target genes of CTNNB1 have not yet been identified in adrenocortical tumors. Our objective was to identify genes de-regulated in adrenocortical tumors harbouring CTNNB1 genetic alter...
ORGANISM(S): Homo sapiens 
2011-04-09 | E-GEOD-28476 | biostudies-arrayexpress
ProteomicsDifferentially expressed proteins in benign and malignant adrenocortical tumors
We have compared the microsomal protein fractions from benign and malignant adrenocortical tumors. Protein extracts were trypsinized, peptides separated by HiRIEF (high resolution isoelectric focusing) and analysed by LC-MS.
ORGANISM(S): Homo sapiens (Human) 
2014-02-11 | PXD000604 | Pride
Microsomal fraction Hirief Lc-ms Isoelectric focusing Adrenocortical tumors Cancer 
TranscriptomicsTranscription profiling by array of human adrenocortical tumors to identify molecular predictors of diagnosis and prognosis
A ""Cartes d'Identite des Tumeurs"" (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net). 92 samples on Affymetrix HG-U133 Plus 2.0 GeneChips arrays for 92 patients with Adrenocortical Tumors (ACT). 4 normal adrenal samples from the same batch are also include...
ORGANISM(S): Homo sapiens 
2009-01-15 | E-TABM-311 | biostudies-arrayexpress
TranscriptomicsDeregulated miRNAs in adrenocortical tumors
We performed miRNA expression profiling in a series of adrenocortical carcinomas, adrenocortical adenomas and normal adreno cortex using a microarray approach. Significant differentially expressed miRNAs among groups were identified using SAM analysis. Agilent microarray platform containing 903 miR...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-22816 | biostudies-arrayexpress
ProteomicsProteomic Profile of Human Benign and Malignant Adrenocortical Neoplasia.
The molecular pathogenesis of adrenocortical diseases, particularly adrenocortical carcinoma (ACC), has advanced considerably in recent years due to the application of high-throughput molecular analysis. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) offers an approach for identifying and...
ORGANISM(S): Homo sapiens (Human) 
2025-12-15 | PXD062822 | Pride
Human adrenal gland Adrenocortical tumors Adrenocortical carcinoma Normal adrenal cortex Adrenocortical adenona Primary macronodular adrenocortical hyperplasia 
TranscriptomicsAdrenocortical Carcinoma Gene Expression Profiling [Affymetrix]
Background: Adrenocortical carcinoma (ACC) is associated with poor survival rates. The objective of the study was to analyze ACC gene expression profiling data prognostic biomarkers and novel therapeutic targets. Methods: 44 ACC and 4 normal adrenal glands were profiled on Affymetrix U133 Plus 2 ex...
ORGANISM(S): Homo sapiens 
2013-11-21 | E-GEOD-19750 | biostudies-arrayexpress
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