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ProteomicsProlyl Hydroxylase Substrate Adenylosuccinate Lyase Is An Oncogenic Driver In Triple Negative Breast Cancer
Protein hydroxylation extensively regulates cellular signaling by affecting protein stability, protein-protein interaction and protein activity, and its dysregulation contributes to the pathogenesis of various diseases including cancers. However, because of the transient nature of the enzyme-substra...
ORGANISM(S): Homo sapiens (Human) 
2020-10-06 | PXD015773 | Pride
Hydroxylation Ptm Breast cancer 
ProteomicsMass spectrometry analysis of in vitro PKCe phosphorylated ADSL
Bacterially purified His-ADSL proteins on Ni-NTA agarose beads were incubated with or without active PKCε in the presence of ATP for an in vitro kinase assay. After centrifugation, the agarose beads were collected and mixed with 30 μL of SDS-PAGE sample loading buffer. The samples were then separate...
ORGANISM(S): Homo sapiens (Human) 
2026-02-16 | PXD074509 | Pride
In vitro kinase assay  lc-ms/ms  phosphorylation 
GenomicsRNA-seq of human pluripotent cells with ancient ADSL
RNA-seq of human pluripotent cells with ancient ADSL
PRJEB32703 | ENA
UnknownThe CRISPR-Cas9 crADSL HeLa transcriptome: A first step in establishing a model for ADSL deficiency and SAICAR accumulation.
Not available
S-EPMC6731210 | biostudies-literature
UnknownStructural and biochemical characterization of human adenylosuccinate lyase (ADSL) and the R303C ADSL deficiency-associated mutation.
Not available
S-EPMC3424377 | biostudies-literature
TranscriptomicsAdenylosuccinate lyase (ADSL) enhances endometrial cancer aggressiveness via increasing killer cell lectin like receptor C3 expression by fumarate
Although ADSL is an enzyme that is involved in de novo purine synthesis, it was reported that ADSL knockdown did not result in decreases in adenine nucleotides (AMP, ADP, and ATP) or GTP. Then, we hypothesized that decreased cell proliferation, migration and invasion capability by ADSL knockdown in ...
ORGANISM(S): Homo sapiens 
2018-03-08 | GSE100703 | GEO
UnknownPathway-specific effects of ADSL deficiency on neurodevelopment.
Not available
S-EPMC8871376 | biostudies-literature
TranscriptomicsRNA-seq of human pluripotent cells with ancient ADSL
To investigate if the amino acid substitution to the ancestral in ADSL results in changes in gene expression in human cells, we isolate RNA from two wildtype control and three ancestralized cell lines. For each line, three independent batches of cultured cells were analyzed.
ORGANISM(S): Homo sapiens 
2019-12-12 | E-MTAB-7979 | biostudies-arrayexpress
UnknownSilencing of Dicer enhances dacarbazine resistance in melanoma cells by inhibiting ADSL expression.
Not available
S-EPMC10713419 | biostudies-literature
UnknownAdenylosuccinate lyase (ADSL) is a pan-cancer prognostic and immune biomarker with distinct roles in hepatocellular carcinoma.
Not available
S-EPMC12627297 | biostudies-literature
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