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ProteomicsNeo N-termiome of SPG7, AFG3L2, SPG7 AFG3L2 and WT HeLa cells
To understand how OMA1 affects mitochondrial proteostasis and stress responses, we performed a proteomic survey of OMA1-deficient cells for proteolytic substrates. We demonstrate that OMA1 cleaves the mitochondrial chaperone DNAJC15 facilitating its degradation by the mitochondrial m-AAA protease. T...
ORGANISM(S): Homo sapiens (Human) 
2025-12-19 | PXD061137 | Pride
Human Neon Spg7 Hela Afg3l2 
ProteomicsCycloheximide time course in WT and AFG3L2 knockout HeLa cells
Mitochondria are metabolically rewired in hypoxia when cells switch to glycolytic growth. In addition to the well-established role of transcriptional and translational programs, there is increasing evidence that post-translational mechanisms contribute to the rapid adaptation of the mitochondrial pr...
ORGANISM(S): Homo sapiens (Human) 
2026-01-06 | PXD056318 | Pride
Cycloheximide Hela Mitochondria Afg3l2 
GenomicsMitochondrial protease Afg3l2 regulates the homeostasis of mouse hematopoietic stem and progenitor cells through Mmadhc [proteomics]
Mitochondrial protease Afg3l2 regulates the homeostasis of mouse hematopoietic stem and progenitor cells through Mmadhc [proteomics]
PRJNA1253635 | ENA
ProteomicsDNAJC15 endog. interactome DSP-aided in WT and AFG3L2-KO HeLa cells
Mitochondria dynamically adapt to cellular stress to ensure cell survival. The stress-regulated mitochondrial peptidase OMA1 orchestrates these adaptive responses, which limits mitochondrial fusion and promotes mitochondrial stress signaling and metabolic rewiring. Here, we show that cellular stress...
ORGANISM(S): Homo sapiens (Human) 
2025-12-16 | PXD070836 | Pride
Dnacj15 Afg3l2 
GenomicsMitochondrial protease Afg3l2 regulates the homeostasis of mouse hematopoietic stem and progenitor cells through Mmadhc [RNA-Seq]
Mitochondrial protease Afg3l2 regulates the homeostasis of mouse hematopoietic stem and progenitor cells through Mmadhc [RNA-Seq]
PRJNA1253621 | ENA
ProteomicsMitochondrial protease Afg3l2 regulates the homeostasis of mouse hematopoietic stem and progenitor cells through Mmadhc [proteomics]
In order to study how mitochondrial proteases function on mouse hematopoietic stem cells, the article constructed Afg3l2 knockout mice. When Afg3l2 was knocked out, mouse hematopoietic stem cells showed HSC depletion accompanied by amino acid accumulation and TCA overactivation. We performed transcr...
ORGANISM(S): Mus Mus musculus 
2025-12-15 | GSE295151 | GEO
TranscriptomicsMitochondrial protease Afg3l2 regulates the homeostasis of mouse hematopoietic stem and progenitor cells through Mmadhc [RNA-Seq]
In order to study how mitochondrial proteases function on mouse hematopoietic stem cells, the article constructed Afg3l2 knockout mice. When Afg3l2 was knocked out, mouse hematopoietic stem cells showed HSC depletion accompanied by amino acid accumulation and TCA overactivation. We performed transcr...
ORGANISM(S): Mus musculus 
2025-12-15 | GSE295143 | GEO
ProteomicsDual regulation of SLC25A39 by AFG3L2 and iron controls mitochondrial glutathione homeostasis
Organelle transporters define metabolic compartmentalization and how this metabolite transport process can be modulated is poorly explored. Here, we discovered that SLC25A39, a mitochondrial transporter critical for mitochondrial glutathione uptake, is a short-lived protein under dual regulation at ...
ORGANISM(S): Homo sapiens (Human) 
2025-03-19 | PXD047327 | Pride
Glutathione Protein quality control Afg3l2 Mitochondrial transporter Iron Slc25a39 
UnknownDissecting Substrate Specificities of the Mitochondrial AFG3L2 Protease.
Not available
S-EPMC6475807 | biostudies-literature
UnknownAFG3L2 supports mitochondrial protein synthesis and Purkinje cell survival.
Not available
S-EPMC3484458 | biostudies-literature
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