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ProteomicsArginine to Cysteine substitutants in lung cancer enhance survival to chemotherapy
Tryptophan and arginine are the two most prominent restrictive amino acids linked to anti-tumor activity. For tryptophan, the induction of indoleamine 2,3-dioxygenase 1 (IDO1) by interferon-gamma (IFNg) secreted by T cells, catabolizes tryptophan to kynurenine to suppress T cell activity. For argini...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD043612 | Pride
Arginine Substituants Keap1 Lung cancer Tryptophan 
TranscriptomicsRibosome profiling of harringtonine-treated SUM1315 cells
SUM1315 were treated with harringtonine, and an untreated control sample was taken. Ribosome profiling was performed on these samples. 1 treated and 1 untreated sample
ORGANISM(S): Homo sapiens 
2016-02-17 | E-GEOD-59815 | biostudies-arrayexpress
UnknownArginine deprivation enriches lung cancer proteomes with cysteine by inducing arginine-to-cysteine substitutants.
Not available
S-EPMC11129317 | biostudies-literature
UnknownABPEPserver: a web application for documentation and analysis of substitutants.
Not available
S-EPMC10239192 | biostudies-literature
TranscriptomicsRibo_seq (aka ribosome profiling) analysis of control and Myc-induced U2OS cells
We used Ribo-seq to examine the effect of Myc activation on protein translation in U2OS cells and correalted these changes with alterations in RNA level measured by RNA-seq on tye same conditions. We also examined these effects in the presence of Torin-1, an inhibitor of mTOR We measure ribosome occ...
ORGANISM(S): Homo sapiens 
2015-11-04 | E-GEOD-66927 | biostudies-arrayexpress
TranscriptomicsWide-scale analysis of alternative polyadenylation (APA) associated with proliferation and transformation using 3'-Seq
We mapped and quantified poly(A) sites in BJ and MCF10A cells under proliferative, arrested and transformed states Two human cell lines (BJ and MCF10A) examined under proliferative, arrested and transformed states
ORGANISM(S): Homo sapiens 
2012-06-18 | E-GEOD-33592 | biostudies-arrayexpress
TranscriptomicsGRO-seq analysis of control and Myc-induced U2OS cells
We used GRO-seq to examine the effect of Myc activation on RNA transcription in U2OS cells. We measure in duplicates gene transcription rates in U2OS cells containing an inducible Myc expression vector that were induced or mock-treated in duplicates for 5 hours.
ORGANISM(S): Homo sapiens 
2015-11-04 | E-GEOD-66928 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of control and Myc-induced U2OS cells
We used RNA-seq to examine the effect of Myc activation on U2OS cells transcriptome. We also examined these effects in the presence of Torin-1, an inhibitor of mTOR We measure gene expression profiles in U2OS cells containing an inducible Myc expression vector that were induced or mock-treated in du...
ORGANISM(S): Homo sapiens 
2015-11-04 | E-GEOD-66789 | biostudies-arrayexpress
TranscriptomicsTranscriptome-profiling (RNA-seq) and Ribosome-profiling (Ribo-seq) of BJ cells treated with Nutlin-3a, an MDM2 inhibitor, which induces p53.
We applied in parallel RNA-Seq and Ribosome-profiling analyses to immortalized human primary BJ fibroblast cells in which p53 was induced by Nutlin-3a RNA-seq, using Illumina HiSeq 2000, was applied to BJ cells treated with Nutlin-3a, at 5 timepoints: 0, 2, 4, 6, 19 hrs Ribosome profiling was applie...
ORGANISM(S): Homo sapiens 
2013-06-01 | E-GEOD-45785 | biostudies-arrayexpress
ProteomicsAnti-tumor immunity induces the presentation of aberrant peptides in melanoma
Many tumors escape by activating multiple cellular pathways that induce immunosuppression. One pivotal immune-suppressive mechanism is the production of tryptophan metabolites along the kynurenine pathway by IFNγ-induced IDO1 enzyme production 4-8. Phase III clinical trials using chemical inhibition...
ORGANISM(S): Homo sapiens (Human) 
2020-12-04 | PXD020224 | Pride
Immune recognition Proteomics Melanoma Tryptophan depletion Immunopeptidomics Aberrant peptides Lc-ms/ms 
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