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MetabolomicsGut microbiota-modulated glutamic acid rejuvenates the quality of oocytes deteriorated by advanced reproductive age

The gut microbiota plays a vital role in maintaining the physiological function of host health and the pathogenesis of various diseases. However, its relationship with maternal age-associated decline in oocyte quality remains elusive. Here, we report that establishment of gut microbiota from youn...

2026-05-07 | MTBLS14062 | MetaboLights
ProteomicsGrowth hormone supplementation reduces aneuploidy and improves the quality of oocytes by activating ERK1/2 pathway in aged mice
The decline in oocyte quality is a limiting factor of female fertility; however, strategies to maintain the oocyte quality of aged women are not available. In this study, we showed that growth hormone (GH) supplementation in vivo not only alleviated the decline in oocyte number caused by aging, but ...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-20 | PXD039147 | Pride
Aneuploidy Oocyte quality Aged oocytes Growth hormone 
ProteomicsProteome analysis of aged mouse oocytes
The proteome changes were quantified in aged mouse oocytes using TMT 6-plex by LC-MS/MS.
ORGANISM(S): Mus musculus (Mouse) 
2022-02-16 | PXD023603 | Pride
Tmt Mouse Oocyte Proteomics. Aging 
TranscriptomicsTranscription profiling of human mature oocytes in relation to age
Background: The development competence of human oocytes declines with increasing age. The objective of this study was to investigate the effect of age on gene expression profile in mature human oocytes.
Methods: mRNA was isolated for whole genome gene expression microarray analysis from metaphase...
ORGANISM(S): Homo sapiens 
2009-12-31 | E-MEXP-2347 | biostudies-arrayexpress
TranscriptomicsStorage time does not modify the gene expression profile of cryopreserved human metaphase II oocytes
Study question: Does storage time impact on transcriptome of slowly frozen cryopreserved human metaphase II (MII) oocytes? Summary answer: For the first time, we demonstrate that the length of cryostorage has no effect on the gene expression profile of human metaphase II oocytes. What is known alrea...
ORGANISM(S): Homo sapiens 
2015-09-19 | E-GEOD-69768 | biostudies-arrayexpress
GenomicsMetformin promotes in vitro maturation of oocytes from aged mice
Metformin promotes in vitro maturation of oocytes from aged mice
PRJNA828407 | ENA
GenomicsNicotinamide mononucleotide supplementation reverses the declining quality of maternally aged oocytes
Nicotinamide mononucleotide supplementation reverses the declining quality of maternally aged oocytes
PRJNA644537 | ENA
GenomicsRNA-Sequencing of Aged Mouse Oocytes with in vivo Nicotinamide Mononucleotide (NMN) Treatment
RNA-Sequencing of Aged Mouse Oocytes with in vivo Nicotinamide Mononucleotide (NMN) Treatment
PRJNA759861 | ENA
TranscriptomicsMaternal age effect on mouse oocytes: new biological insight from proteomic analysis
The long-standing view of 'immortal germ line versus mortal soma' poses a fundamental question in biology concerning how oocytes age in molecular terms. A mainstream hypothesis is that maternal aging of oocytes has its roots in gene transcription. Investigating the proteins resulting from mRNA trans...
ORGANISM(S): Mus musculus 
2014-04-15 | E-GEOD-42959 | biostudies-arrayexpress
GenomicsPlat safeguards aged mouse oocytes against programmed cell death through activating the Erk1/2 pathway
Plat safeguards aged mouse oocytes against programmed cell death through activating the Erk1/2 pathway
PRJNA1183336 | ENA
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