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TranscriptomicsRole of Ado1p in the transcriptional response associated with AICAr supplementation
We investigated the role of Ado1p associated with AICAr supplementation on the global transcriptome of Y3188. The Y3188 strain was grown with or without AICAr. For each comparison, we made 2 biological replicates, swapping dyes.
ORGANISM(S): Saccharomyces cerevisiae 
2011-08-31 | E-GEOD-29020 | biostudies-arrayexpress
TranscriptomicsEffect of 5-amino-4-imidazolecarboxamide ribotide (AICAr) supplementation on global transcription
We investigated the effects of AICAr supplementation on the global transcriptome of Y2950. The Y2950 strain was grown with or without AICAr. For each comparison, we made 2 biological replicates, swapping dyes.
ORGANISM(S): Saccharomyces cerevisiae 
2011-08-31 | E-GEOD-29019 | biostudies-arrayexpress
TranscriptomicsAICAR can modulate the expression of microRNA in J1 mESC
We have demonstrated AICAR can maintain J1 mouse ES cells pluripotency in our previous research, yet its effects on ES cells miRNAs expression remain a mystery. In this study, we performed small RNA (sRNA) High-throughput sequencing using Illumina HiSeq 2000 to investigate the influence of AICAR on ...
ORGANISM(S): Mus musculus 
2014-02-06 | E-GEOD-54586 | biostudies-arrayexpress
TranscriptomicsEffect of AICAr and SAICAr accumulation on global transcription in the ade3 mutant
We investigated the effects of AICAr and SAICAr accumulation on the global transcriptome of yeast, comparing the ade3 mutant to the WT strain. The ade3 mutant strain (Y4143) was compared to the WT strain (Y2946). For each comparison, we made 2 technical replicates, swapping dyes.
ORGANISM(S): Saccharomyces cerevisiae 
2011-08-31 | E-GEOD-29021 | biostudies-arrayexpress
TranscriptomicsRNA-seq of U937 cells treated with AICAr
U937 cells were treated wth 0.2 mM AICAr for 24 h to compare the results on cell line know to differentiate in the presence of AICAr with the results on primary patient sample.
ORGANISM(S): Homo sapiens 
2020-11-15 | E-MTAB-9537 | biostudies-arrayexpress
TranscriptomicsIdentifying CHIR99021 and AICAR-regulated genes in the J1 mESCs
It has been demonstrated that CHIR99021 promotes self-renewal of mouse embryonic stem cells, however, the target genes of CHIR99021 is not fully understood. AICAR is the activator of AMP-activated protein kinase. It is reported that AICAR plays important role in mouse embryonic stem cells, however t...
ORGANISM(S): Mus musculus 
2013-01-01 | E-GEOD-40959 | biostudies-arrayexpress
TranscriptomicsTranscriptome of primary acute myeloid leukemia (AML) cells treated with AICAr
Ribonucleoside AICAr, a precursor in purine synthesis and a known activator of AMPK, was shown to induce monocytic differentiation in AML cell lines by inducing pyrimidine depletion followed by activation of ATR/Chk1 pathway and cell cycle arrest. Here we report transcriptional changes induced by AI...
ORGANISM(S): Homo sapiens 
2020-11-01 | E-MTAB-9209 | biostudies-arrayexpress
ProteomicsInsulin and 5-aminoimidazole-4-carboxamide Ribonucleotide (AICAR) Differentially Regulate the Skeletal Muscle Cell Secretome
Skeletal muscle is a major contributor to whole-body glucose homeostasis and is an important endocrine organ. To date, few studies have undertaken the large-scale identification of skeletal muscle-derived secreted proteins (myokines), particularly in response to stimuli that activate pathways govern...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-15 | PXD025687 | Pride
Muscle Metabolism Insulin Secretome Aicar Lcms 
GenomicsMechanisms of AICAR in lung cancer
Mechanisms of AICAR in lung cancer
PRJNA816863 | ENA
GenomicsAICAR regulate IEGs expression in ALL cells
AICAR regulate IEGs expression in ALL cells
PRJNA640928 | ENA
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