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ProteomicsProteomics reveals ablation of PlGF down-regulate the insulin resistance pathway, increase antioxidant and neuroprotective proteins in the diabetic mice retina
PGF (Placental growth factor) is a member of the vascular endothelial growth factor (VEGF) sub-family a crucial factor in angiogenesis and vasculogenesis. Mechanisms by which PlGF expression is regulated remain to be investigated in diabetic retinopathy DR. However, the underlying molecular mechanis...
ORGANISM(S): Mus musculus (Mouse) 
2019-03-13 | PXD010757 | Pride
Akita mice Proteomics Mass spectrometry Diabetes Plgf-knockout 
GenomicsRNAseq analysis of whole islets from pre-weaning wild type and Akita mice
RNAseq analysis of whole islets from pre-weaning wild type and Akita mice
PRJNA473141 | ENA
UnknownNrf2 deficiency deteriorates diabetic kidney disease in Akita model mice.
Not available
S-EPMC9641024 | biostudies-literature
UnknownAugmenting podocyte injury promotes advanced diabetic kidney disease in Akita mice.
Not available
S-EPMC3985087 | biostudies-literature
UnknownIncreased inflammation in atherosclerotic lesions of diabetic Akita-LDLr⁻/⁻ mice compared to nondiabetic LDLr⁻/⁻ mice.
Not available
S-EPMC3515907 | biostudies-literature
UnknownType 1 diabetic Akita mice have low bone mass and impaired fracture healing.
Not available
S-EPMC8546917 | biostudies-literature
TranscriptomicsRNAseq analysis of whole islets from pre-weaning wild type and Akita mice
This study aims to determine the effects of proinsulin misfolding/ER stress on β-cell dynamics and function in Akita mice. The RNAseq experiment offers the opportunity to investigate the impact of proinsulin misfolding/ ER stress on the genetic signature of islets isolated during the neonatal period...
ORGANISM(S): Mus musculus 
2018-12-02 | GSE114927 | GEO
UnknownInvestigation of Retinal Metabolic Function in Type 1 Diabetic Akita Mice.
Not available
S-EPMC9201036 | biostudies-literature
UnknownCardiac transcriptome profiling of diabetic Akita mice using microarray and next generation sequencing.
Not available
S-EPMC5570368 | biostudies-literature
TranscriptomicsExpression data from the transplanted mouse islets into hyperglycemic and normoglycemic mice at 6 hours post-transplantation
insulin treatment protects islets from the initial rapid loss that is usually observed after transplantation and positively affects the outcome of islet transplantation in Akita mice. To study the molecular mechanism underlying the improved islet survival, expression profile analyses was performed t...
ORGANISM(S): Mus musculus 
2014-04-18 | E-GEOD-55764 | biostudies-arrayexpress
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