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ProteomicsA Pore-Forming Toxin Monalysin Contributes to Infection-Induced Suppression of Defecation in Female Drosophila
Pathogen expulsion from the gut via defecation is an important defence strategy against infection. The microbial factors that can subvert this defence reaction remain poorly understood. While many microbes have been found to increase host intestinal peristalsis, Pseudomonas entomophila infection in ...
ORGANISM(S): Pseudomonas entomophila L48 
2026-08-18 | PXD071560 | Pride
Defecation Pseudomonas entomophila Pore-forming toxin Monalysin Proteomics Intestinal peristalsis Hfq Drosophila melanogaster 
ProteomicsTargeting the translation machinery: The RNase Y specificity factor Y-complex coordinates ribosome degradation
Limiting the synthesis and activity of ribosomes is crucial for responding to various stresses, including nutrient starvation or proteotoxic stress. In Bacillus subtilis, this is achieved through the coordinated action of the alarmones (p)ppGpp and the transcription factor Spx. In this study, we per...
ORGANISM(S): Bacillus subtilis 
2026-04-09 | PXD065462 | Pride
Rnase y Ribosome Bacillus subtilis 
ProteomicsStress-induced ribosome degradation in Bacillus subtilis is mediated by the RNase Y-specificity complex
Limiting the synthesis and activity of ribosomes is crucial for responding to various stresses, including nutrient starvation or proteotoxic stress. In Bacillus subtilis, this is achieved through the coordinated action of the alarmones (p)ppGpp and the transcription factor Spx. In this study, we per...
ORGANISM(S): Bacillus subtilis 
2026-04-09 | PXD065465 | Pride
ProteomicsStress-induced ribosome degradation in Bacillus subtilis is mediated by the RNase Y-specificity complex
Limiting the synthesis and activity of ribosomes is crucial for adaptation to stresses, such as heat or nutrient starvation. In Bacillus subtilis, this can be achieved through the coordinated action of the alarmones (p)ppGpp and the transcription factor Spx. Here, we performed a genetic screen to un...
ORGANISM(S): Bacillus sp. B-23280 
2026-04-09 | PXD074523 | Pride
ProteomicsIMPROVED N- AND O-GLYCOPEPTIDE IDENTIFICATION USING HIGH-FIELD ASYMMETRIC WAVEFORM ION MOBILITY SPECTROMETRY (FAIMS)
Mass spectrometry is the premier tool for identifying and quantifying site-specific protein glycosylation globally. Analysis of intact glycopeptides often requires an enrichment step, after which the samples remain highly complex and exhibit a broad dynamic range of abundance. Here, we evaluated th...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD038673 | Pride
Faims N-glycopeptides Mass spectrometry O-glycopeptides Glycoproteomics 
ProteomicsA novel RNA binding protein YebC enhances translation of proline-rich amino acid stretches in bacteria
The ribosome employs a set of highly conserved translation factors to efficiently synthesise proteins. Some translation factors interact with the ribosome in a transient manner and are thus challenging to identify. However, proteins involved in translation could be specifically identified by their i...
ORGANISM(S): Streptococcus pyogenes M1 GAS 
2025-07-14 | PXD054642 | Pride
Streptococcus pyogenes Rna binding protein Rna Rna-protein xl 
ProteomicsCaspase-4 and Caspase-5 Coordinate the Sensing of Streptococcus pyogenes Extracellular vesicles
Caspase-4 and caspase-5 have been linked to the sensing of Gram-negative bacteria and their extracellular vesicles (EVs). Recent studies suggested that Gram-positive bacteria can be sensed through signaling cascades involving these two caspases. In the present study, we report that S. pyogenes secre...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD046570 | Pride
S. pyogenes Nlrp3 Caspases 
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