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ProteomicsAn XPC-PARP axis links ALC1-mediated chromatin remodeling to global genome DNA damage repair
Cells employ global genome DNA damage repair (GGR) to eliminate a broad spectrum of DNA lesions, including those induced by UV light. The lesion-recognition factor XPC initiates repair of helix-distorting DNA lesions, but binds inefficiently to lesions that cause poor helix distortion. How such diff...
ORGANISM(S): Homo sapiens (Human) 
2022-07-15 | PXD025226 | Pride
Parp2 Parp1 Xpc Gg-ner Alc1 
ProteomicsMultiple roles for PARP1 in ALC1-dependent nucleosome remodeling
XL-MS mass spectrometry analysis Cross-linked peptides were resolved for mass spectrometry analysis using a Dionex UltiMate 3000 RSLnano liquid chromatography system. Peptides were initially loaded from the autosampler onto an Acclaim PepMap 100 C18 LC Trap Cartridge (0.3 mm inside diameter, 5 mm le...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-04-10 | MSV000087174 | MassIVE
GenomicsALC1 and PARP activities coordinate chromatin accessibility and viability in homologous recombination deficient cells (RNA-seq)
ALC1 and PARP activities coordinate chromatin accessibility and viability in homologous recombination deficient cells (RNA-seq)
PRJNA627391 | ENA
GenomicsALC1 and PARP activities coordinate chromatin accessibility and viability in homologous recombination deficient cells (ATAC-seq)
ALC1 and PARP activities coordinate chromatin accessibility and viability in homologous recombination deficient cells (ATAC-seq)
PRJNA634143 | ENA
GenomicsALC1 and PARP activities coordinate chromatin accessibility and viability in homologous recombination deficient cells (ATAC-seq)
The response to Poly (ADP-ribose) polymerase inhibitors (PARPi) is dictated by homologous recombination (HR) DNA repair mechanisms and the abundance of lesions that trap PARP enzymes on chromatin. It remains unclear, however, if the established role of PARP in promoting chromatin accessibility impac...
ORGANISM(S): Homo sapiens 
2020-12-02 | GSE150955 | GEO
TranscriptomicsALC1 and PARP activities coordinate chromatin accessibility and viability in homologous recombination deficient cells (RNA-seq)
The response to Poly (ADP-ribose) polymerase inhibitors (PARPi) is dictated by homologous recombination (HR) DNA repair mechanisms and the abundance of lesions that trap PARP enzymes on chromatin. It remains unclear, however, if the established role of PARP in promoting chromatin accessibility impac...
ORGANISM(S): Homo sapiens 
2020-12-02 | GSE149104 | GEO
UnknownMechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1.
Not available
S-EPMC5745148 | biostudies-literature
UnknownALC1/CHD1L, a chromatin-remodeling enzyme, is required for efficient base excision repair.
Not available
S-EPMC5693467 | biostudies-literature
UnknownMechanistic Insights into Regulation of the ALC1 Remodeler by the Nucleosome Acidic Patch.
Not available
S-EPMC7116876 | biostudies-literature
UnknownStructural basis of ALC1/CHD1L autoinhibition and the mechanism of activation by the nucleosome.
Not available
S-EPMC8249414 | biostudies-literature
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