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ProteomicsAn XPC-PARP axis links ALC1-mediated chromatin remodeling to global genome DNA damage repair
Cells employ global genome DNA damage repair (GGR) to eliminate a broad spectrum of DNA lesions, including those induced by UV light. The lesion-recognition factor XPC initiates repair of helix-distorting DNA lesions, but binds inefficiently to lesions that cause poor helix distortion. How such diff...
ORGANISM(S): Homo sapiens (Human) 
2022-07-15 | PXD025226 | Pride
Parp2 Parp1 Xpc Gg-ner Alc1 
GenomicsFunctional and Mechanistic Studies of XPC DNA-Repair Complex as Transcriptional Coactivator in Embryonic Stem Cells
We recently identified the DNA repair complex XPC-RAD23B-CETN2 as a stem cell coactivator (SCC) required for OCT4 and SOX2 transcriptional activation. Here we investigate genome-wide the role of SCC in murine ESCs by mapping regions bound by its RAD23B subunit in wild type and Xpc-/- ESCs, and analy...
ORGANISM(S): Mus musculus 
2015-04-20 | E-GEOD-64040 | biostudies-arrayexpress
ProteomicsMS-based quantitative proteomic analysis of UVB irradiation in XPC-deficient keratinocytes
Xeroderma Pigmentosum C (XPC) is a DNA damage recognition protein central to the global genome nucleotide excision repair (GG-NER) pathway, where it acts as a primary sensor of UV-induced DNA lesions. Loss-of-function mutations in the XPC gene lead to a photosensitive phenotype, with marked accumula...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD069309 | Pride
Human Keratinocytes Xp-c disease Nanolc-ms/ms Uvb 
ProteomicsProteome characterization of XPC-deficient melanocytes generated by CRISPR-Cas9 technology reveals alteration in the expression of several hundred of proteins
Xeroderma pigmentosum (XP) is a rare autosomal recessive disorder owing to the defects in one of the factors implicated in nucleotide excision repair (NER) system. The effect of NER deficiency on melanocyte biology has not received much attention up to now from a mechanistic standpoint, due to the l...
ORGANISM(S): Homo sapiens (Human) 
2024-12-17 | PXD042713 | Pride
Immune system Xeroderma pigmentosum Melanocyte Proteomic 
TranscriptomicsThe C-terminal region of Xpc is dispensable for the transcriptional activity of Oct3/4 in mouse embryonic stem cells
The transcription factor Oct3/4 is essential to maintain pluripotency in mouse embryonic stem (ES) cells. It was reported that the Xpc DNA repair complex is involved in this process. Here we examined the role of Xpc on the transcriptional activation of the target genes by Oct3/4 using the inducible ...
ORGANISM(S): Mus musculus 
2015-06-09 | E-GEOD-69640 | biostudies-arrayexpress
TranscriptomicsBenzo(a)pyrene induces similar gene expression changes in testis of DNA repair proficient and deficient male mice
DNA damage induced by benzo(a)pyrene may lead to the formation of mutations and as a consequence to the development of diseases. However, it is uncertain whether benzo(a)pyrene causes heritable mutations in male germ cells, which would increase health risks in offspring. In a previous study, benzo(a...
ORGANISM(S): Mus musculus 
2010-08-23 | E-GEOD-17979 | biostudies-arrayexpress
TranscriptomicsXPC_UV
xpc-1 mutant animals were treated with 60mJ/cm2 UVB irradiation or mock treated to derive gene expression response to UVB induced DNA damage
ORGANISM(S): Caenorhabditis elegans 
2013-08-27 | E-MTAB-1689 | biostudies-arrayexpress
Methylation profilingEffects of XPC overexpression on global methylation
The study examines the impact of XPC overexpression on DNA demethylation in human dermal fibroblasts (HDFs) and during the early phase of somatic cell reprogramming (pre-iPSCs). We profiled the 5mC status in wild type and XPC gain-of-function HDFs and pre-iPSCs on a genome-wide scale by MeDIP-seq. X...
ORGANISM(S): Homo sapiens 
2017-05-22 | GSE92445 | GEO
GenomicsRNA-seq for L1 stage wildtype, csb-1 and xpc-1 C.elegans
RNA-seq for L1 stage wildtype, csb-1 and xpc-1 C.elegans
PRJNA1177893 | ENA
UnknownRecognition of DNA damage by XPC coincides with disruption of the XPC-RAD23 complex.
Not available
S-EPMC3308700 | biostudies-literature
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