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MetabolomicsMulti-omic responses of mouse liver and skeletal muscle to chronic alcohol drinking

The aim of this study was to define and compare the molecular blueprints of chronic alcohol use in the liver and skeletal muscle using an established pre-clinical mouse model.

2025-12-11 | MTBLS12616 | MetaboLights
TranscriptomicsGene expression data from brain nucleus accumbens shell (Acb-sh) following binge-like alcohol drinking by adolescent alcohol-preferring rats
The objective of this study was to determine changes in gene expression within the extended amygdala following binge-like alcohol drinking by adolescent alcohol-preferring (P) rats. Starting at 28 days of age, P rats were given concurrent access to 15 and 30 % ethanol for 3 one-h sessions for 5 cons...
ORGANISM(S): Rattus norvegicus 
2013-07-20 | E-GEOD-49041 | biostudies-arrayexpress
TranscriptomicsGene expression data from brain central nucleus of amygdala (CeA) following binge-like alcohol drinking by adolescent alcohol-preferring rats
The objective of this study was to determine changes in gene expression within the extended amygdala following binge-like alcohol drinking by adolescent alcohol-preferring (P) rats. Starting at 28 days of age, P rats were given concurrent access to 15 and 30 % ethanol for 3 one-h sessions for 5 cons...
ORGANISM(S): Rattus norvegicus 
2013-07-20 | E-GEOD-49040 | biostudies-arrayexpress
MetabolomicsIntegrated Analyses of the Gut Microbiota, Intestinal Permeability and Serum Metabolome Phenotype in Rats with Alcohol Withdrawal Syndrome
The etiology of alcohol dependence is not completely understood. Increasing evidence reveals that gut microbiota dysbiosis is associated with certain psychiatric disorders, including alcoholism, through the 'microbiota-gut-brain' axis. The aims were to evaluate the effect of alcohol abuse on the gut...
2021-07-30 | MTBLS2688 | MetaboLights
MetabolomicsList of metabolites of human feces of control and alcohol-exposed groups

To explore the diet-microbiome-host-drug efficacy axis in chronic alcohol-increased anaesthetic use. Fecal metabolites were comprehensively extracted, detected and analyzed to identify differential metabolic profiles induced by chronic alcohol consumption, providing a basis for revealing the corr...

2026-01-25 | MTBLS13761 | MetaboLights
TranscriptomicsThe Nucleus Accumbens Shell and Central Nucleus of the Amygdala of Alcohol-Preferring Rats Following Binge-Drinking
The objective of this study was to determine changes in gene expression within the extended amygdala following binge-like drinking by alcohol-preferring (P) rats. Adult male P rats were given 1-hr access to 15 and 30% ethanol (EtOH) three times daily for 8 weeks. Rats (n = 10/time point for EtOH and...
ORGANISM(S): Rattus norvegicus 
2009-12-30 | E-GEOD-15407 | biostudies-arrayexpress
TranscriptomicsGenes associated with alcohol abuse and nicotine addiction in the human nucleus accumbens
Background: The incidence of alcohol and tobacco co-abuse is as high as 80%. The molecular mechanism underlying this comorbidity is virtually unknown but interactions between these drugs have important implications for the development of, and recovery from drug dependence. Methods: We investigat...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-20568 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rats from inbred alcohol-preferring and -non-preferring strains in five brain regions
The objective of this study was to test the hypothesis that innate differences in gene expression in the brain could; contribute to the differences in alcohol drinking or response to alcohol between adult male inbred alcohol-preferring (iP) and -non-preferring; (iNP) rats. Gene expression was determ...
ORGANISM(S): Rattus norvegicus 
2008-11-22 | E-GEOD-4494 | biostudies-arrayexpress
TranscriptomicsGenomic Analysis of Individual Differences in Ethanol Drinking: Evidence for Non-genetic Factors in C57BL/6 Mice
Here, we identify persistent and substantial variation in ethanol drinking behavior within an inbred mouse strain and utilize this model to identify gene networks influencing such non-genetic variation in ethanol intake. C57BL/6NCrl mice showed persistent inter-individual variation of ethanol intake...
ORGANISM(S): Mus musculus 
2011-03-01 | E-GEOD-26506 | biostudies-arrayexpress
TranscriptomicsmicroRNA Expression based, Effects of Chronic Intermittent Ethanol paradigm on mouse brain
We analyzed cerebral cortices (CTX) and midbrains (MB) from male C57BL/6J mice subjected to a CIE, 2BC paradigm, which induces heavy drinking and represents one of the best available animal models for alcohol dependence and relapse drinking. Samples from CTX and MB of 21 mice: 7 Naïve, 7 Air-2BC, an...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-48576 | biostudies-arrayexpress
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