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ProteomicsMulti-omics integration reveals convergent extracellular matrix remodeling and lipid metabolic reprogramming as central axes of adipocyte differentiation from mouse embryonic stem cells
Adipose tissue dysfunction is a hallmark of obesity and type 2 diabetes mellitus, yet the full molecular complexity of adipocyte differentiation remains incompletely characterized. Single-omics approaches capture only partial dimensions of this multi-layered biological transition. Here, we applied a...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-08 | PXD078584 | Pride
Adipogenesis  mouse embryonic stem cells  multi-omics integration  extracellular matrix remodeling  lipidomics  mofa+  multi-omics factor analysis 
UnknownExploring the medicinal potential of Dark Chemical Matters (DCM) to design promising inhibitors for PLpro of SARS-CoV-2 using molecular screening and simulation approaches.
Not available
S-EPMC10504533 | biostudies-literature
ProteomicsThe Calmodulin/Striatin Interaction is Enhanced in Diabetic Hearts and Defines Novel Signaling Clusters implicated in Cardiac Remodeling
Diabetic cardiomyopathy (DbCM) halts cardiac performance with a complex etiology, hence the absence of an effective therapy for this disease. Herein we decoded the proteins hub interconnected with Calmodulin (CaM), a striatin (STRN) binding protein, that plays a role in DbCM. Using CaM as a bait, we...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-06-15 | PXD069737 | Pride
Lc-msms Rat Tmt Cardiac left ventricles 
UnknownKinetics of cellulase-free endo xylanase hyper-synthesis by Aspergillus Niger using wheat bran as a potential solid substrate.
Not available
S-EPMC11438087 | biostudies-literature
UnknownIn Vitro Biofilm-Mediated Biodegradation of Pesticides and Dye-Contaminated Effluents Using Bacterial Biofilms.
Not available
S-EPMC10535849 | biostudies-literature
UnknownOral Regimens for Rifampin-Resistant, Fluoroquinolone-Susceptible Tuberculosis.
Not available
S-EPMC7617355 | biostudies-literature
UnknownManagement of subcutaneous abscesses: prospective cross-sectional study (MAGIC).
Not available
S-EPMC11334058 | biostudies-literature
UnknownA multinational cross-sectional study on the prevalence and predictors of long COVID across 33 countries.
Not available
S-EPMC12319108 | biostudies-literature
UnknownEffects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study.
Not available
S-EPMC9210173 | biostudies-literature
UnknownGlobal variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries.
Not available
S-EPMC7846817 | biostudies-literature
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