Sort   by:  
 Page size 
ProteomicsEnglerin A rewires phosphosignaling via HSP27 hyperphosphorylation to induce cytotoxicity in renal cancer cells
Englerin A (EA) is a small molecule natural product with selective cytotoxicity against renal cancer cells. EA has been shown to induce apoptosis and cell death through cell cycle arrest and/or insulin signaling pathways. However, its specific biological mode of action or targets in renal cancer rem...
ORGANISM(S): Homo sapiens (Human) 
2022-07-25 | PXD034333 | Pride
Hsp27 Anti-cancer drug Phosphoproteomics Renal cancer Englerin a 
ProteomicsComprehensive proteomic characterization reveals subclass-specific molecular aberrations within triple-negative breast cancer
Triple-negative breast cancer (TNBC) is regarded as the most aggressive subtype of breast cancer lacking targeted therapies. This is attributed to its high heterogeneity that complicates elucidation of its molecular aberrations. Here, we report identification of specific proteome expression profiles...
ORGANISM(S): Homo sapiens (Human) 
2020-03-03 | PXD017025 | Pride
Triple-negative Tnbc Proteomics Mass spectrometry Protease Breast cancer Kinase 
ProteomicsSystem-wide vitreous proteome dissection reveals impaired sheddase activity in diabetic retinopathy
Diabetic retinopathy (DR) is a major complication of diabetes mellitus causing significant vision loss. Despite the success of anti-VEGF therapy as an effective therapy, many DR patients do not respond well to the treatment, emphasizing the involvement of other molecular players. To unveil these, we...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD036033 | Pride
Vitreous humor/diabetic retinopathy/ectodomain shedding/sheddase 
ProteomicsDual-function thermogelling polymers as effective endotamponade for retinal detachment repair and reassembly of vitreous-like body in-situ
Endo-tamponade agents are crucial surgical adjuncts for vitreo-retinal surgery. Current clinical agents provide internal tamponade through buoyancy forces requiring the need for prolonged facing down post-operative positioning. Other disadvantages include temporary loss of vision, raised intra-ocula...
ORGANISM(S): Oryctolagus cuniculus (Rabbit) 
2019-09-13 | PXD009525 | Pride
Eye Vitreous Thermogelling polymer Retinal detachment repair Rabbit 
OtherFunctional Mapping of the Zebrafish Early Embryo Proteome and Transcriptome
Data from PeptideAtlas, [[http://www.peptideatlas.org/PASS/PASS00444 PASS00444]]. Replicate: 2, experiment: G_120105_01_zebrafish_band3, file: folder summary. Published as part of J Proteome Res. 2014 Sep 17 . From the Abstract: {{i}} Zebrafish is a popular system for studying vertebrate developmen...
ORGANISM(S): Fish_e 
GPM32310004416 | GPMDB
ProteomicsMultiomics Analyses Reveal Dynamic Bioenergetic Pathways and Functional Remodeling of the Heart During Intermittent Fasting
Intermittent fasting (IF) reduces cardiovascular risk factors in animals and humans, and can protect the heart against ischemic injury in models of myocardial infarction, but the underlying molecular mechanisms are unknown. To delineate molecular perturbations in response to IF, we carried out compr...
ORGANISM(S): Mus musculus (Mouse) 
2023-09-27 | PXD015452 | Pride
Intermittent fasting Heart Proteome Mice Phosphoproteome Transcriptome 
Sort   by:  
 Page size