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GenomicsAllosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression
Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression
PRJNA544318 | ENA
ProteomicsDistinct modulation of cellular immunopeptidome by the allosteric regulatory site of ER aminopeptidase 1
ER aminopeptidase 1 (ERAP1) is an ER-resident aminopeptidase that excises N-terminal residues off peptides that then bind onto Major Histocompatibility Complex I molecules (MHC-I) and indirectly modulates adaptive immune responses. ERAP1 contains an allosteric regulatory site that accommodates the C...
ORGANISM(S): Homo sapiens (Human) 
2023-11-21 | PXD039584 | Pride
Hla Mhc class1 Inhibitor Erap1 Aminopetidase Immunopeptidomics Allosteric 
TranscriptomicsAllosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression
Using machine learning to identify biological targets for natural products with anticancer properties and unknown modes of action is gaining momentum. Herein, we employ machine intelligence to deconvolute the phenotypic effects of the natural product Piperlongumine (PL) and establish an unprecedente...
ORGANISM(S): Homo sapiens 
2019-05-23 | GSE131660 | GEO
ProteomicsSmall Molecule Allosteric inhibitors of GPX4
Encouraged by the dependence of drug-resistant, metastatic cancers on GPX4, we examined biophysical mechanisms of GPX4 inhibition, which revealed an unexpected allosteric binding site. We found that this site was involved in native modulation of GPX4 activity. Binding of inhibitors to this allosteri...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-10-12 | MSV000090526 | MassIVE
GenomicsSmall molecule probe for IBD risk variant GPR65 I231L alters cytokine signaling networks through positive allosteric modulation
Small molecule probe for IBD risk variant GPR65 I231L alters cytokine signaling networks through positive allosteric modulation
PRJNA1019398 | ENA
UnknownCovalent allosteric modulation: An emerging strategy for GPCRs drug discovery.
Not available
S-EPMC9948676 | biostudies-literature
UnknownMolecular Insights into Metabotropic Glutamate Receptor Allosteric Modulation.
Not available
S-EPMC4468636 | biostudies-literature
GenomicsGenetic and functional modulation by agonist MRS5698 and allosteric enhancer LUF6000 at the native A3 adenosine receptor in HL-60 cells.
Genetic and functional modulation by agonist MRS5698 and allosteric enhancer LUF6000 at the native A3 adenosine receptor in HL-60 cells.
PRJNA1289178 | ENA
UnknownMechanism of Allosteric Modulation of the Cys-loop Receptors.
Not available
S-EPMC4033940 | biostudies-literature
ModelsLai2014 - Hemiconcerted MWC model of intact calmodulin with two targets
Lai2014 - Hemiconcerted MWC model of intact calmodulin with two targets This model is described in the article: Modulation of calmodulin lobes by different targets: an allosteric model with hemiconcerted conformational transitions. Lai M, Brun D, Edelstein SJ, Le Novère N. ...
2024-09-02 | BIOMD0000000574 | BioModels
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