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TranscriptomicsTranscription profiling of human post mortem spinal cord grey matter from sporadic and familial ALS patients vs controls to identify amyotrophic lateral sclerosis (ALS) associated genes
Identification of amyotrophic lateral sclerosis (ALS) associated genes. Post mortem spinal cord grey matter from sporadic and familial ALS patients compared with controls.
ORGANISM(S): Homo sapiens 
2007-09-26 | E-GEOD-833 | biostudies-arrayexpress
ProteomicsSynaptic proteomics reveal distinct molecular signatures of cognitive change and C9ORF72 repeat expansion in the human ALS cortex
Increasing evidence suggests synaptic dysfunction is a central and possibly triggering factor in Amyotrophic Lateral Sclerosis (ALS). Despite this, we still know very little about the molecular profile of an ALS synapse. To address this gap, we designed a synaptic proteomics experiment to perform an...
ORGANISM(S): Homo sapiens (Human) 
2022-11-09 | PXD037393 | Pride
Synapse Proteomics C9orf72 Human brain Als Ftd 
ProteomicsConvergent Activation of the Integrated Stress Response and ER–Mitochondria Uncoupling in VAPB-Associated ALS
Human iPSC-derived motor neurons with either VAPB WT or VAPB P56S expressed under the control of a doxycycline inducible promoter were grown out to day 35 of motor neuron differentiation. A co-immunoprecipitation was then performed using the VAPB protein as bait to determine the interactome of VAPB ...
ORGANISM(S): Homo sapiens (Human) 
2025-09-15 | PXD065524 | Pride
Als type viii Mitochondria Vapb Isr Isrib Er-mam Als Neurodegeneration 
TranscriptomicsDistinct and shared functions of ALS-associated TDP-43, FUS, and TAF15 revealed by comprehensive multi-system integrative analyses [RNA-Seq_human]
TDP-43, FUS, and TAF15 are implicated in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. We integrate CLIP-seq and RNA Bind-N-Seq technologies to discover that TAF15 binds to ~4,900 RNAs enriched for GGUA motifs. In the mouse brain, TAF15 and FUS, but not TDP-43, exhibit strikingly ...
ORGANISM(S): Homo sapiens 
2016-07-05 | E-GEOD-77702 | biostudies-arrayexpress
TranscriptomicsDistinct and shared functions of ALS-associated TDP-43, FUS, and TAF15 revealed by comprehensive multi-system integrative analyses [RNA-Seq_Stability]
TDP-43, FUS, and TAF15 are implicated in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. We integrate CLIP-seq and RNA Bind-N-Seq technologies to discover that TAF15 binds to ~4,900 RNAs enriched for GGUA motifs. In the mouse brain, TAF15 and FUS, but not TDP-43, exhibit strikingly ...
ORGANISM(S): Homo sapiens 
2016-07-05 | E-GEOD-77704 | biostudies-arrayexpress
UnknownInhibitory interneurons show early dysfunction in a SOD1 mouse model of amyotrophic lateral sclerosis.
Not available
S-EPMC9898203 | biostudies-literature
ProteomicsThe BPAN disease protein WDR45 forms condensates with Caprin-1 to regulate stress granule disassembly
Beta-propeller protein-associated neurodegeneration (BPAN) is a rare X-linked neurodegenerative disorder primarily caused by mutations in the WD repeat domain 45 (WDR45) gene. While WDR45 has traditionally been linked to autophagy, our study uncovers a previously unrecognized role for WDR45 as a cri...
ORGANISM(S): Homo Sapiens 
PXD062911 |
ProteomicsContext-dependent and disease-specific diversity in stress granules formed from preexisting protein interactions
Affinity-capture proteomics studies using endogenously tagged G3BP1 with APEX2 to capture the stress granule proteome at steady state and upon stress induction. This was done in 293T cells as well as induced pluripotent stem cells differentiated into neuronal progenitor cells.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000081554 | MassIVE
TranscriptomicsA hidden threshold in motor neuron gene networks for survival revealed by modulation of miR-218 dose
miRNAs are post-transcriptional repressors with wide variation in cellular abundance across cell types and disease states. Yet, the transcriptomic and biological impact of altering miRNA levels (rather than binary gain or loss) has not been systematically investigated. By genetic combination, we gen...
ORGANISM(S): Mus musculus 
2021-08-27 | E-MTAB-10571 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human motor cortex in sporadic amyotrophic lateral sclerosis
We used oligonucleotide microarrays to find differentially expressed genes between control subjects and those affected by sporadic amyotrophic lateral sclerosis. Experiment Overall Design: Complementary RNAs (cRNAs) labelled with Cy5-CTP (Perkin-Elmer) were synthesized from 1 µg of total RNA of eac...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-4595 | biostudies-arrayexpress
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