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ProteomicsComparative proteomics of extracellular vesicles derived from wildtype or mutant EMCV-infected cells
Non-enveloped viruses, such as picornaviruses, can escape infected host cells via release in extracellular vesicles (EVs) prior to the induction of lysis. These EVs cloak the secreted virus particles in a host-derived membrane, which alters virus-host interactions that affect infection efficiency an...
ORGANISM(S): Homo sapiens (Human) 
2022-06-02 | PXD033906 | Pride
Extracellular vesicles (evs) Lc-ms Picornaviruses 
ProteomicsProteomic analysis uncover a new function and mode of action for mDia2
mDia2 is an auto-inhibited Formin influencing actin dynamics upon conversion to the active conformation. mDia2 regulates actin-based protrusions and cell invasion, cell differentiation, vesicle trafficking and cytokinesis. However, whether mDia2 has additional functions and how its action is functio...
ORGANISM(S): Homo sapiens (Human) 
2015-01-06 | PXD000175 | Pride
Ap-ms Proteomics Mdia2 
ProteomicsCombining high resolution and exact calibration to boost statistical power: A well-calibrated score function for high-resolution MS2
This project reanalzyes data from 4 other projects. Information about the samples can be found in the following four publications. The four samples used in this study include a ocean metaproteome sample, a human sample, a E. coli sample, and a Plamodium falciparum sample. B. N. Pease, E. L. Huttli...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum (isolate 3D7) Escherichia coli 
2018-09-19 | PXD009265 | Pride
E. coli Score function Ocean Human Plasmodium 
MetabolomicsCysteamine-bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis
Nephropathic cystinosis is a severe monogenic kidney disorder caused by mutations in CTNS, encoding the lysosomal transporter cystinosin, resulting in lysosomal cystine accumulation. The sole treatment, cysteamine, slows down the disease progression, but does not correct the established renal proxim...
2021-06-24 | MTBLS2538 | MetaboLights
ProteomicsDeciphering the protein dynamics and molecular determinants of iPSC-derived neurons.
Neuronal development is a multistep process with different regulatory programs that shapes neurons to form dendrites, axons and synapses. To date, knowledge on neuronal development is largely based on murine data and largely restricted to the genomic and transcriptomic level. Advances in stem cell d...
ORGANISM(S): Homo sapiens (Human) 
2020-05-07 | PXD013399 | Pride
Ipsc  human  neuron differentiation  quantitative mass spectrometry  tmt-10plex 
UnknownDaily rhythms in the cyanobacterium synechococcus elongatus probed by high-resolution mass spectrometry-based proteomics reveals a small defined set of cyclic proteins.
Not available
S-EPMC4125736 | biostudies-literature
ProteomicsAn Optimized Suspension Trapping (S-Trap) Method for Phosphoproteomics Sample Preparation
The performance of the S-Trap protocol for phosphoproteomics studies for proteome and phosphoproteome was systematically evaluated in big-scale and small-scale samples. The results showed the existing protocol was problematic for phsophopeptides enrichment. After employing optimized S-Trap methodol...
ORGANISM(S): Homo sapiens (Human) 
2023-06-19 | PXD037751 | Pride
Phosphoproteomics  sample preparation  method optimization 
ProteomicsTemporal quantitative proteomics of mGluR-induced protein translation and phosphorylation in neurons
At neuronal synapses, activation of group I metabotropic glutamate receptors (mGluR1/5) triggers a form of long-term depression (mGluR-LTD) that relies on new protein synthesis and the internalization of AMPA-type glutamate receptors. Dysregulation of these processes has been implicated in the devel...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-09-11 | PXD014043 | Pride
Synaptic plasticity Proteomics Protein translation Metabolic labeling Ampa receptor Mglur-ltd Phosphoproteomics Bioorthogonal amino acid tagging Tandem mass tags 
ProteomicsElucidating Fibroblast Growth Factor-induced kinome dynamics using targeted mass spectrometry and dynamic modeling
Fibroblast growth factors (FGFs) are paracrine or endocrine signaling proteins that when activated by their ligands, can elicit a wide range of healthy and disease-related processes such as cell proliferation and the epithelial-to-mesenchymal transition (EMT). The detailed molecular pathway dynamics...
ORGANISM(S): Homo sapiens (Human) 
2023-07-02 | PXD038836 | Pride
Phosphoproteomics  kinase  targeted mass spectrometry  kinase dynamics  fibroblast growth factors  dynamic modeling  fibroblast growth factor receptor  breast cancer.  
ProteomicsElucidating Fibroblast Growth Factor-induced kinome dynamics using targeted mass spectrometry and dynamic modeling
Fibroblast growth factors (FGFs) are paracrine or endocrine signaling proteins that when activated by their ligands, can elicit a wide range of healthy and disease-related processes such as cell proliferation and the epithelial-to-mesenchymal transition (EMT). The detailed molecular pathway dynamics...
ORGANISM(S): Homo sapiens (Human) 
2023-07-02 | PXD038808 | Pride
Phosphoproteomics  kinase  targeted mass spectrometry  kinase dynamics  fibroblast growth factors  dynamic modeling  fibroblast growth factor receptor  breast cancer.  
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