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ProteomicsSignalling Inhibition by Ponatinib Disrupts Productive Alternative Lengthening of Telomeres (ALT)
Alternative lengthening of telomeres (ALT) supports telomere maintenance and replicative immortality in around 10-15% of cancers, thus representing a compelling target for therapy.To identify anti-cancer drugs that can be repurposed as ALT-centered therapies, we performed for a compound library scre...
ORGANISM(S): Homo sapiens (Human) 
2023-02-20 | PXD037501 | Pride
Telomeres Alt Ponatinib Sarcoma Jun 
GenomicsCharacterization of PAXIP1 in alternative lengthening of telomeres
Characterization of PAXIP1 in alternative lengthening of telomeres
PRJNA1389466 | ENA
ProteomicsTRIM24 directs replicative stress responses to maintain ALT telomeres via chromatin signaling
An inability to replicate the genome can cause replication stress and genome instability. Here, we develop BLOCK-ID, a proteomic method to identify and visualize proteins at stressed replication forks. This approach successfully identified novel mediators of the replication stress response, includin...
ORGANISM(S): Homo sapiens (Human) 
2026-08-31 | PXD063658 | Pride
Trim24  block-id  replication stress  alt  telomeres  sumoylation 
GenomicsFunctional loss of ATRX and telomerase activates Alternative Lengthening of Telomeres (ALT)
Functional loss of ATRX and telomerase activates Alternative Lengthening of Telomeres (ALT)
PRJNA531393 | ENA
GenomicsSignalling inhibition by ponatinib disrupts alternative lengthening of telomeres (ALT)
Signalling inhibition by ponatinib disrupts alternative lengthening of telomeres (ALT)
PRJNA787207 | ENA
ProteomicsTRIM24 directs replicative stress responses to maintain ALT telomeres via chromatin signaling
An inability to replicate the genome can cause replication stress and genome instability. Here, we develop BLOCK-ID, a proteomic method to identify and visualize proteins at stressed replication forks. This approach successfully identified novel mediators of the replication stress response, includin...
ORGANISM(S): Homo sapiens (Human) 
2026-08-31 | PXD057112 | Pride
Telomeres Block-id Replication stress Trim24 Sumoylation 
GenomicsNR2C/F orphan receptors induce telomere-genome rearrangements in ALT
Most sarcomas have complex karyotype and are characterized by multiple chromosomal rearrangements. Moreover, sarcomas very frequently maintain their telomeres by recombination in the process called Alternative Lengthening of Telomeres (ALT) which enables their continuous growth and immortalization. ...
ORGANISM(S): Homo sapiens 
2015-02-23 | E-GEOD-46237 | biostudies-arrayexpress
UnknownThe FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT).
Not available
S-EPMC6538672 | biostudies-literature
UnknownAlternative lengthening of telomeres is a self-perpetuating process in ALT-associated PML bodies.
Not available
S-EPMC8245000 | biostudies-literature
UnknownSignalling inhibition by ponatinib disrupts productive alternative lengthening of telomeres (ALT).
Not available
S-EPMC10079688 | biostudies-literature
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