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TranscriptomicsGSTM3 single nucleotide polymorphism (rs7483) associated with peripheral BMC expression in Alzheimer disease
Comparisons between the sample groups (normal elderly control (NEC) and Alzheimer disease (AD)) allowed the identification of genes with disease expression patterns associated with the glutathione S-transferase M3 single nucleotide polymorphism rs7483. Keywords: biological repeat Peripheral blood mo...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-4227 | biostudies-arrayexpress
TranscriptomicsBrain microvessel: Alzheimer disease vs normal
The enigma that is Alzheimer's disease (AD) continues to present daunting challenges for effective therapeutic intervention. The lack of disease-modifying therapies may, in part, be attributable to the narrow research focus employed to understand this complex disease. Most studies into disease patho...
ORGANISM(S): Homo sapiens 
2013-03-29 | E-GEOD-45596 | biostudies-arrayexpress
TranscriptomicsExpression profiling of laser-microdissected tissue from APPPS1 plaque-depositing mouse model of Alzheimer's disease
Amyloid-M-CM-^_ (AM-CM-^_) plaques are pathological hallmarks of Alzheimer disease. However, the precise neuropathological changes that occur in brain in response to amyloid deposition are largely unknown. To study the molecular mechanism(s) responsible for AM-CM-^_-mediated neuropathology, we perfo...
ORGANISM(S): Mus musculus 
2014-11-04 | E-GEOD-15058 | biostudies-arrayexpress
TranscriptomicsExpression profiling of laser-microdissected tissue from Tg2576 plaque-depositing mouse model of Alzheimer's disease
Amyloid-M-CM-^_ (AM-CM-^_) plaques are pathological hallmarks of Alzheimer disease. However, the precise neuropathological changes that occur in brain in response to amyloid deposition are largely unknown. To study the molecular mechanism(s) responsible for AM-CM-^_-mediated neuropathology, we perfo...
ORGANISM(S): Mus musculus 
2014-11-04 | E-GEOD-15056 | biostudies-arrayexpress
TranscriptomicsInduced pluripotent stem cell-derived neurons from a sporadic Alzheimer disease donor as a model for investigating disease mechanisms
Gene expression analysis of control fibroblasts (NFH2), one AD-derived fibroblasts (NFH-46), NFH2-derived control-iPS cells (OiPS3, OiPS6), NFH46-derived AD-iPS cells (iPS5 and iPS 26B), hESCs (H1 and H9). Total mRNA obtained from AD fibroblasts (NFH-46) and control fibroblasts (NFH-2), from plurip...
ORGANISM(S): Homo sapiens 
2015-04-21 | E-GEOD-42492 | biostudies-arrayexpress
Genomics5-Hydroxymenthylation-associated Epigenetic Modifiers in Alzheimer's disease
Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by progressive deterioration of cognitive function. Evidence suggests a role for epigenetic regulation, in particular the cytosine modifications 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC,) in AD. 5hmC is hi...
ORGANISM(S): Homo sapiens 
2016-07-20 | E-GEOD-72782 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Alzheimers disease patients to identify genes regulating synaptic function and neuroplasticity in incipient AD
In Alzheimer's disease (AD), early deficits in learning and memory are a consequence of synaptic modification which are likely induced by toxic beta-amyloid oligomers (dAbeta). To identify molecular targets downstream of dAbeta binding we prepared synaptoneurosomes from frontal cortex of control a...
ORGANISM(S): Homo sapiens 
2009-01-17 | E-GEOD-12685 | biostudies-arrayexpress
ProteomicsAlzheimer's disease proteomics
This project aims to determine how the brain proteome is remodeled in Alzheimer's disease (AD). AD is pathologically characterized by an accumulation of insoluble aggregates composed of Abeta peptides in the brain and is clinically characterized by progressive memory impairment. While the precise pa...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2016-12-19 | MSV000080431 | MassIVE
TranscriptomicsGenes and Pathways Underlying Regional and Cell Type Changes in Alzheimer's Disease
Along with the two hallmark pathologies—intracellular neurofibrillary tangles (NFTs) and extracellular amyloid plaques—transcriptional studies suggest that Alzheimer's disease (AD) results from dysfunction of many cellular pathways including synaptic transmission, cytoskeletal dynamics, and apoptosi...
ORGANISM(S): Homo sapiens 
2013-06-07 | E-GEOD-29378 | biostudies-arrayexpress
TranscriptomicsExpression data from non-demented controls (NDCs) and Alzheimer's disease (AD) patients
AD is the leading cause of dementia in the elderly. However, disease etiology is still practically unknown. To gain insight into the molecular mechanisms underlying this disease we used the Affymetrix exon arrays to profile the alternative splicing landscape of human entorhinal cortex samples from A...
ORGANISM(S): Homo sapiens 
2012-09-06 | E-GEOD-26972 | biostudies-arrayexpress
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