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MetabolomicsDysregulation of Streptococcus pneumoniae zinc homeostasis breaks ampicillin resistance in a pneumonia infection model

Streptococcus pneumoniae is the primary cause of community-acquired bacterial pneumonia with rates of penicillin and multi-drug resistance exceeding 80% and 40%, respectively. The innate immune response generates a variety of antimicrobial agents to control infection including zinc stres...

2022-02-23 | MTBLS318 | MetaboLights
ProteomicsProteomics Study of Filamentous Persisters from Evo3A Evolved Populations during Ampicillin Treatment and Resuscitation
Proteomics is the most suitable tool to study persisters with their complex underlying molecular mechanisms from a system-level perspective, but the number of persisters that present naturally is too few for proteomics analysis. Here, we utilized Evo3A, an evolved population with enriched persisters...
ORGANISM(S): Escherichia coli 
2020-07-13 | PXD016271 | Pride
Antibiotic Resuscitation Β-lactam Proteomics Persisters Ampicillin Filaments 
TranscriptomicsEnterococcus faecalis OG1RF control vs. treatment with ampicillin, bacitracin, or cephalothin
Transcriptional profiling to investigate the effect of drug treatment on the E. faecalis cells. For microarray analysis, E. faecalis OG1RF was grown in FMC medium supplemented with 10 mM glucose to an optical density at 600 nm (OD600) of 0.3 and the cultures were divided in 7 aliquots. One aliquot w...
ORGANISM(S): Enterococcus faecalis OG1RF 
2013-03-16 | E-GEOD-45231 | biostudies-arrayexpress
MetabolomicsGut metabolomics of 6PPD-Q exposed mice with ABX treatment

Untargeted fecal metabolomics using UHPLC-MS/MS to analyze microbiota-dependent metabolic changes in C57BL/6 mice exposed to 6PPD-quinone (6PPD-Q) with/without antibiotic-mediated gut microbiota depletion. Key pathways include tryptophan and nicotinamide metabolism linked to intestinal barrier fu...

2026-09-15 | MTBLS14308 | MetaboLights
MetabolomicsElucidating the molecular mechanisms of Daifu decoction in ulcerative colitis treatment through a multi-omics framework and experimental verification

Background: Ulcerative colitis (UC) is a significant and challenging condition in the digestive system, necessitating the development of effective therapeutic interventions. The Daifu decoction (DFD) is derived from the Lizhong decoction, a classic traditional Chinese Medicine (TCM) formula used ...

2026-03-18 | MTBLS13973 | MetaboLights
GenomicsAmpicillin treatment casues dysbiosis that persists until study endpoint [RNA-seq]
Ampicillin treatment casues dysbiosis that persists until study endpoint [RNA-seq]
PRJNA575802 | ENA
ProteomicsProteomics Analysis of Evolved Escherichia coli Populations from Cyclic Antibiotic Treatment
When the survivors of antibiotic treatment (persisters) are repeatedly regrown and retreated with the same antibiotic for several cycles, the new population will soon adapt to the treatment condition and become tolerant to the drug. Here, we did evolution experiments on Escherichia coli populations ...
ORGANISM(S): Escherichia coli 
2020-01-10 | PXD013326 | Pride
Proteomics Persistence Antibiotic Persisters Evolved populations 
TranscriptomicsTranscriptional profiling of Drosophila during Listeria infection as they die and as they recover upon ampicillin treatment
Transcriptional profiling of Drosophila during Listeria infection as they die and as they recover upon ampicillin treatment
ORGANISM(S): Drosophila melanogaster 
2016-04-18 | GSE60985 | GEO
TranscriptomicsBW25113 H202 and delta rpoS persister cells vs. stationary phase BW25113 wild-type
E. coli K-12 BW25113 persister cells generated via H202 pre-treatment and deletion of rpoS, relative to BW25113 wild-type stationary phase gene expression. Persister cells were generated following exposure to ampicillin 20 ug/mL. Strains: BW25113 wild-type, pre-treated with H202 10 min, ampicillin 5...
ORGANISM(S): Escherichia coli 
2012-04-02 | E-GEOD-34028 | biostudies-arrayexpress
TranscriptomicsAmpicillin treatment (100 ug/ml) in M9 + glucose, timecourse
Responses of Escherichia coli as they are treated to 100 ug/ml Ampicillin in M9 + glucose Keywords: time course
ORGANISM(S): Escherichia coli 
2006-03-08 | GSE4357 | GEO
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