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TranscriptomicsResponse of human lymphoblastoid cells to HZE (iron ions) or gamma-rays
Transcriptional profiling of human lymphoblastoid TK6 cells comparing mock irradiated cells with cells exposed 24 hours previously to 1.67 Gy HZE (1 GeV/amu iron ions accelerated at the NASA Space Research Laboratory (NSRL) of Brookhaven National Laboratory) or 2.5 Gy 137Cs gamma rays. TK6 cells wer...
ORGANISM(S): Homo sapiens 
2011-04-01 | E-GEOD-16518 | biostudies-arrayexpress
TranscriptomicsMicroarray profiles of radiation response in the NCI60 cell lines
The 60 cell lines of the NCI Anti-Cancer Drug Screen (NCI60) constitute the most extensively characterized in vitro cancer cell model, and have been tested for sensitivity to over 100,000 potential chemotherapy agents. We have used the NCI60 cell lines and three additional lymphoblast lines to deve...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-7505 | biostudies-arrayexpress
TranscriptomicsIMR90 4hr bystander experiment 0.5Gy alpha particle strip dish format
Radiation affects tissue and cellular integrity at the level of DNA, protein and metabolites of the cell and extracellular space. The effects of radiation are not limited to targeted cells and tissue and radiation induced bystander effects are significant to exposed individuals in accidental or ...
ORGANISM(S): Homo sapiens 
2008-12-28 | E-GEOD-12435 | biostudies-arrayexpress
TranscriptomicsIMR90 radiation bystander time-course experiment 0.5Gy alpha particle
The radiation bystander effect is an important component of the overall biological response of tissues and organisms to ionizing radiation. Little is known about the contribution of genome level changes in neighboring bystander cells to tissue and organ stress after irradiation. The timing of these ...
ORGANISM(S): Homo sapiens 
2011-01-14 | E-GEOD-21059 | biostudies-arrayexpress
TranscriptomicsResponse of the EPI-200 human 3-D skin model to high and low doses of protons
Accumulating data suggest that the biological responses to high and low doses of radiation are qualitatively different, necessitating the direct study of low dose responses. Most such studies have utilized 2-dimensional culture systems, which may not fully represent responses in 3-dimensional tissue...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-GEOD-16935 | biostudies-arrayexpress
TranscriptomicsIMR90 bystander experiment 0.5 Gy alpha particle
The existence of a radiation bystander effect, in which non-irradiated cells respond to signals from irradiated cells, is well established. It raises concerns for the interpretation of risks from exposure to low doses of ionizing radiation. Sparse data exists about the bystander signaling mechanisms...
ORGANISM(S): Homo sapiens 
2010-07-21 | E-GEOD-18760 | biostudies-arrayexpress
TranscriptomicsGene expression in male and female smokers
Smoking is the second leading cause of preventable death in the United States. Cohort epidemiological studies have demonstrated that women are more vulnerable to cigarette-smoking induced diseases than their male counterparts, however, the molecular basis of these differences has been remained unkn...
ORGANISM(S): Homo sapiens 
2015-05-01 | E-GEOD-47415 | biostudies-arrayexpress
TranscriptomicsRadiation-induced bystander effects and gene expression in cells deficient for RAD9
Background: The radiation bystander response is an important component of the overall response of cells to radiation and critical to understanding health risks of radiation exposure to humans. The mechanism of radiation response includes inter-cellular signaling and intra-cellular communication by w...
ORGANISM(S): Homo sapiens 
2014-10-07 | E-GEOD-55869 | biostudies-arrayexpress
TranscriptomicsGene expression in blood of mice with internal exposure to Cs-137
Cesium-137 is a radionuclide of concern in fallout from reactor accidents or nuclear detonations. When ingested or inhaled, it can expose the entire body for an extended period of time, potentially contributing to serious health consequences ranging from acute radiation syndrome to increased cancer...
ORGANISM(S): Mus musculus 
2014-08-31 | E-GEOD-52690 | biostudies-arrayexpress
TranscriptomicsTotal-body irradiation dose response
Duplicate hybridizations with fluorochrome switching were performed following the first two fractions of total body irradiation for accumulated doses of 1.5 Gy and 3.0 Gy. Control samples for all hybridizations were from the same patient before the beginning of treatment.
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-1366 | biostudies-arrayexpress
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