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MetabolomicsAnalyzing nicotine action against amyloid toxicity by NMR-pharmacometabolomics: an exploratory study

Alzheimer's disease (AD) is the primary neurodegenerative disease spread worldwide. One of the main histopathological hallmarks of AD is amyloid plaque deposition in the brain. Despite some epidemiological studies demonstrating that cigarette smoke is a factor in predisposing people to AD, nicoti...

2026-06-26 | MTBLS12706 | MetaboLights
TranscriptomicsTranscription profiling of human cholinergic SN56.B5.G4 cells treated with beta-amyloid or hydrogen peroxide
Effect of beta-Amyloid and oxidative stress on gene expression in cholinergic SN56.B5.G4-cells
ORGANISM(S): Mus musculus 
2005-01-01 | E-MEXP-710 | biostudies-arrayexpress
TranscriptomicsModulation of gene expression by complement protein C1q in amyloid-beta injured neurons
Complement protein C1q is induced after injury in the brain and during Alzheimer's disease and has been shown to protect against amyloid-beta induced neuronal death. In this study, we used microarray approach to identify the pathways modulated by C1q that are associated with neuroprotection. Immatur...
ORGANISM(S): Rattus norvegicus 
2012-12-21 | E-GEOD-28886 | biostudies-arrayexpress
ProteomicsProfiling of the proteins interacting with amyloid beta peptides in clinical samples by PACTS-TPP
Analysis and identification of Aβ1-42 peptide interaction protein in clinical samples.
ORGANISM(S): Homo Sapiens 
2024-05-23 | PXD052500 |
TranscriptomicsTranscription profiling of rat astrocytes cultured on the beta-amyloid peptide 25-35 fragment for 12 hours, 1, 3 and 5 days
Cortical type-I astrocytes were cultured on the beta-amyloid peptide 25-35 fragment for 12hr, 1d, 3d, and 5d.
ORGANISM(S): Rattus norvegicus 
2007-10-12 | E-GEOD-856 | biostudies-arrayexpress
TranscriptomicsComparative transcriptome profiling of Amyloid Precursor Protein APP family members in the adult cortex
The β-amyloid precursor protein APP and the related APLPs, undergo complex proteolytic processing giving rise to several fragments. Whereas it is well established that Aβ accumulation is a central trigger for Alzheimer disease (AD), the physiological role of APP family members and their diverse pr...
ORGANISM(S): Mus musculus 
2011-03-18 | E-GEOD-25926 | biostudies-arrayexpress
ProteomicsChlorpyrifos oxon crosslinking of amyloid beta 42 peptides is a new route for generation of self-aggregating amyloidogenic oligomers that promote Alzheimer’s disease
Epidemiological evidence suggests that people chronically exposed to organophosphorus pesticides are at increased risk of neurodegenerative disease. Covalently linked amyloid beta dimers have been isolated from the brains of Alzheimer’s patients. The toxic forms of amyloid beta are amyloid dimers ...
ORGANISM(S): Homo sapiens (Human) 
2022-07-17 | PXD034163 | Pride
Chlorpyrifos oxon Amyloid beta Isopeptide Crosslinks 
GenomicsssDNA aptamers against amyloid-β peptide as biomarker and inhibtor [SELEX]
ssDNA aptamers against amyloid-β peptide as biomarker and inhibtor [SELEX]
PRJNA514043 | ENA
ModelsSteckmann2012 - Amyloid beta-protein fibrillogenesis (kinetics of secondary structure conversion)
Steckmann2012 - Amyloid beta-protein fibrillogenesis (kinetics of secondary structure conversion) This model is described in the article: Kinetics of peptide secondary structure conversion during amyloid ?-protein fibrillogenesis. Steckmann T, Awan Z, Gerstman BS, Chapagain ...
2024-09-02 | BIOMD0000000533 | BioModels
TranscriptomicsTranscription profiling of human neuroblastoma cell line SH-SY5Y transfected to produce phenotypes with low, medium or high levels of beta-amyloid peptides with 40 or 42 amino acids
Alzheimer's disease (AD) is characterized by massive neurodegeneration and multiple changes in cellular processes, including neurogenesis. Proteolytic processing of the amyloid precursor protein (APP) plays a central role in AD. Due to varying APP processing, several beta-amyloid peptides are genera...
ORGANISM(S): Homo sapiens 
2009-06-01 | E-MEXP-1913 | biostudies-arrayexpress
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