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HKU1 is a human betacoronavirus and infects host cells via highly glycosylated spike protein (S). At present, N-glycosylation of HKU1 S has been reported, however, little is known about its O-glycosylation, which hinders an in-depth understanding of its biological functions. Herein, a comprehensive ...
ORGANISM(S): Human coronavirus HKU1 (isolate N1) 
2022-02-17 | PXD025967 | Pride
Deciphering the crosstalk between metabolic reprogramming and epigenetic regulation is a promising strategy for cancer therapy. In this study, we discovered that the gluconeogenic enzyme PCK1 fuels the generation of S-adenosylmethionine (SAM) through the serine synthesis pathway. The methyltransfera...
2025-08-09 | MTBLS7651 | MetaboLights
Polycyclic aromatic hydrocarbons (PAHs) are widely distributed, carcinogenic environmental contaminants produced as a consequence of the incomplete combustion of fossil fuels. Benzo[a]pyrene (BaP) is a very extensively studied prototypical PAH. We recently reported a complete lack of change in micro...
ORGANISM(S): Mus musculus 
Proteomics screening of the DEPs of the normal and GDM maternal placentas was conducted by using isobaric tags for relative and absolute quantitation (iTRAQ). The bioinformatics analysis was performed on DEPs, and parallel reaction monitoring (PRM) was used to verify the DEPs. Sixty-eight DEPs in G...
ORGANISM(S): Homo Sapiens 
2022-04-17 | PXD033280 |
The molecular mechanisms underlying the sex differences in human muscle morphology and function remain to be elucidated. The purpose of the study was to detect the sex differences in the skeletal muscle transcriptome in both the resting state and following anabolic stimuli, resistance exercise. We u...
ORGANISM(S): Homo sapiens 
Metabolic fatty liver disease (MAFLD) has become the most common chronic liver disease worldwide, with steatosis as the underlying pathology. At the same time, MAFLD is also a high-risk factor for the development of metabolic diseases. Shenling Baizhu powder (SLP) is a traditional Chinese herbal for...
ORGANISM(S): Rattus Norvegicus 
2023-05-07 | PXD042049 |
P. yezoensis is an economically important marine crop and highly used seafood in China containing a high number of proteiP. yezoensis is an economically important marine crop and highly used seafood in China containing a high number of proteins. An oomycete, known as Pythium porphyrae, causes the re...
ORGANISM(S): Pyropia yezoensis 
2018-12-03 | PXD009363 | Pride
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