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Bacteria can resist antibiotics and toxic substances within demanding ecological settings, such as low oxygen, extreme acid, and during nutrient starvation. MdtEF, a proton motive force-driven efflux pump from the resistance-nodulation-cell division (RND) superfamily, is upregulated in these cond...

2025-09-26 | MTBLS13050 | MetaboLights
Polyketide synthases (PKSs) are modular enzymes with exceptional potential as biocatalysts for producing non-native compounds. Here, we report the first PKS-based pathway for adipic acid (AA), an industrial monomer for nylon production, by engineering one of the most extensively hybridized PKS syste...
ORGANISM(S): Pseudomonas putida KT2440 
2026-09-07 | PXD069956 | Pride
Metagenomic sequencing provides a window into microbial community structure and metabolic potential; however, linking these data to exogenous metabolites that microorganisms process and produce (the exometabolome) remains challenging. Previously, we observed strong exometabolite niche partitioning a...
2018-07-31 | MTBLS492 | MetaboLights
Uptake and fixation of CO2 are central to strategies for CO2-based biomanufacturing. Cupriavidus necator H16 has emerged as a promising industrial host for this purpose. Despite its prominence, the ability to engineer C. necator inorganic carbon uptake and fixation is underexplored. Here, we test th...
ORGANISM(S): Cupriavidus necator 
2026-01-23 | PXD051976 | Pride
Monoterpenes are commonly known for their role in the flavors and fragrances industry and are also gaining attention for other uses like insect repellant and as potential renewable fuels for aviation. Corynebacterium glutamicum, a Generally Recognized as Safe microbe, has been a choice organism in i...
ORGANISM(S): Corynebacterium glutamicum 
2024-02-28 | PXD044193 | Pride
Our group has evaluated the productivity of the alcohol isoprenol (3-methyl-3-buten-1-ol), platform commodity chemical with attractive properties specifically as a diesel fuel blendstock and precursor for the bio-jetfuel DMCO, across a number of microbial hosts. While there are strengths and drawbac...
ORGANISM(S): Pseudomonas putida KT2440 
2025-09-12 | PXD061547 | Pride
This project aimed to assess the role of pharmacological inhibition of the aryl hydrocarbon receptor (AhR) on skeletal muscle and cortical bone health in aged mice. As part of a broader systems biology approach, proteomic profiling was employed to investigate molecular mediators of neuromuscular jun...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-06 | PXD065529 | Pride
This study investigates the serum proteome dynamics of male Hilsa (Tenualosa ilisha), a species of significant ecological and economic importance, to better understand its functional roles in conservation, aquaculture, and population sustainability.
ORGANISM(S): Tenualosa ilisha 
2025-05-20 | PXD062121 | Pride
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