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ProteomicsProteomics reveals the function reverse of MPSSS treated prostate cancer-associated fibroblasts to suppress PC-3 cell viability via the FoxO pathway
Prostate cancer (PCa) remains the malignancy with the highest morbidity in men (1). Although early-stage PCa usually causes no symptoms, cancer cells in prostate glands readily metastasize to bones, lymph nodes, lungs, and liver during PCa progression (2). Common strategies, including surgery, radia...
ORGANISM(S): Homo sapiens (Human) 
2021-03-22 | PXD023689 | Pride
Human Proteomics Prostate cafs Secretomics Prostate cancer cells Lc-ms/ms 
GenomicsAn improved SELEX-Seq strategy for characterizing DNA-binding specificity of transcription factor: NF-M-NM-:B as an example
We provided an improved SELEX-Seq strategy for characterizing DNA-binding specificity of transcription factor. We valided the strategy by characterzing the DNA-binding specificty of NF-M-NM-:B p50 dimer. Proteins of the Nf-kappab family were bound to DNA oligonucleotides containing a degenerate regi...
ORGANISM(S): Homo sapiens 
2014-05-05 | E-GEOD-48660 | biostudies-arrayexpress
MetabolomicsL-fucose and fucoidan alleviate high-salt diet-promoted acute inflammation

Excessive salt intake is a widespread health issue observed in almost every country around the world. A high salt diet (HSD) has a strong correlation with numerous diseases, including hypertension, chronic kidney disease and autoimmune disorders. However, the mechanisms underlying HSD-promotion o...

2024-02-21 | MTBLS9134 | MetaboLights
MetabolomicsMetabolomic analysis of alfalfa (Medicago sativa L.) root-symbiotic rhizobia responses under alkali stress
Alkaline salts (e.g., NaHCO3 and Na2CO3) causes more severe morphological and physiological damage to plants than neutral salts (e.g., NaCl and Na2SO4) due to differences in pH. The mechanism by which plants respond to alkali stress is not fully understood, especially in plants having symbotic relat...
2018-07-27 | MTBLS481 | MetaboLights
ProteomicsIntegrating metabolic and evolutionary engineering for enhanced propionic acid production under cross stress: a multi-omics perspective
We performed a combination of metabolic engineering (deletion of ldh and poxB and overexpression of mmc) with evolutionary engineering (selection under oxygen stress, acid stress and osmotic stress) in Propionibacterium acidipropionici. The results indicated that the mutants had superior physiologic...
ORGANISM(S): Acidipropionibacterium acidipropionici 
2020-04-27 | PXD016616 | Pride
Omics analysis Cross stress Metabolic and evolutionary engineering Propionibacterium acidipropionici Propionic acid 
ProteomicsProteomic analysis of mouse samples including the bEnd.3 cells conditioned mediums and treated primary astrocytes.
10 samples which include the bEnd.3 cells conditioned medium and treated primary astrocytes were analyzed with LC-MS/MS.
ORGANISM(S): Mus musculus (Mouse) 
2026-03-26 | PXD036816 | Pride
MetabolomicsYinchenhao Decoction ameliorates high-fat diet-induced lipid metabolism disorder

In this study, a HFD-induced lipid metabolism disorder model was established in C57BL/6 mice in vivo, and a palmitic acid (PA)-induced hepatocyte lipid accumulation model was constructed in HepG2 cells in vitro. Using component identification, network pharmacology, transcriptome sequencing, molec...

2027-06-26 | MTBLS14689 | MetaboLights
MetabolomicsHuanglianjiedu Decoction ameliorates high-fat diet-induced lipid metabolism disorder
In this study, a HFD-induced lipid metabolism disorder model was established in C57BL/6 mice in vivo, and a palmitic acid (PA)-induced hepatocyte lipid accumulation model was constructed in HepG2 cells in vitro. Using component identification, network pharmacology, transcriptome sequencing, molecula...
2026-08-26 | MTBLS14701 | MetaboLights
UnknownMicroRNA signatures in chemotherapy resistant esophageal cancer cell lines.
Not available
S-EPMC4209553 | biostudies-literature
ProteomicsResistance prediction in HGSOC with NACT using data-independent acquisition proteomics and an ovarian tissue-specific spectral library
We firstly built a high-quality ovarian tissue-specific spectral library containing 130,735 peptides and 10,696 proteins on Orbitrap instruments. Compared to a published pan-human spectral library (DPHL), this spectral library provides 10% more ovary-specific and 3% more ovary-enriched proteins. Thi...
ORGANISM(S): Homo Sapiens 
2023-01-02 | PXD039160 |
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