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ProteomicsMacro-porous Reversed Phase Separation of Proteins Combined with Reversed Phase Separation of Phosphopeptides and Tandem Mass Spectrometry for Profiling the Phosphoproteome of MDA-MB-231 cells
A new method of combining macro-porous reversed phase (mRP) protein fractionation with reversed phase liquid chromatography (RPLC) peptide separation tandem mass spectrometry (MS/MS) is reported for profiling the phosphoproteome of a complex sample. In this method, an mRP-C18 column was used to frac...
ORGANISM(S): Homo sapiens (Human) 
2014-07-24 | PXD000948 | Pride
Phosphoproteome Mrp-rplc Scx-rplc Mda-mb-231 Mass spectrometry 
MetabolomicsTherapeutic effects of traditional Chinese medicine compound Hua-Feng-Dan in a rat model of ischemic stroke involve renormalization of gut microbiota

Hua-Feng-Dan is a traditional Chinese medicine compound used to treat ischemic stroke, but little is known about its therapeutic mechanism. This study explored whether and how the mechanism involves readjustment of gut microbiota. Rats were subjected to middle cerebral artery occlusion as a model...

2025-01-06 | MTBLS10818 | MetaboLights
UnknownThe O-glycosylating enzyme GALNT2 acts as an oncogenic driver in non-small cell lung cancer.
Not available
S-EPMC9440866 | biostudies-literature
UnknownEnhancing hospital protection measures reduces frontline medical workers' stress during the pandemic.
Not available
S-EPMC11613736 | biostudies-literature
ProteomicsThe role of IRAKM in IL-1β-treated adipocytes
Toll-like receptors/Interleukin-1 receptor (IL-1R) signaling plays an important role in High-fat diet (HFD)-induced adipose tissue dysfunction contributing to obesity-associated metabolic syndromes. Here, we show an unconventional IL-1R-IRAKM (IL-1R-associated kinase M)-Slc25a1 signaling axis in adi...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-09 | PXD031934 | Pride
Irakm Fatty acid synthesis Pgc1a acetylation Adipocytes Slc25a1 
TranscriptomicsMicroarray analysis of Wolbachia infected Anopheles gambiae Sua5B cells
Wolbachia, an endosymbiotic bacterium, is being investigated as a vector control agent in several insect species. Along with the well known classical reproductive parasitism Wolbachia employs against its host to spread within the population, it is emerging that the bacteria can protect the host agai...
ORGANISM(S): Anopheles gambiae 
2011-03-02 | E-GEOD-23215 | biostudies-arrayexpress
ProteomicsProteomic and metabolomic signatures associated with the immune response in healthy individuals immunized with an inactivated SARS-CoV-2 vaccine
CoronaVac (Sinovac), an inactivated vaccine for SARS-CoV-2, has been widely used for immunization. However, analysis of the underlying molecular mechanisms driving CoronaVac-induced immunity is still limited. Here, we applied a systems biology approach to understand the mechanisms behind the adaptiv...
ORGANISM(S): Homo Sapiens 
2022-03-09 | PXD032127 |
UnknownIn situ Metabolomics of Metabolic Reprogramming Involved in a Mouse Model of Type 2 Diabetic Kidney Disease.
Not available
S-EPMC8670437 | biostudies-literature
UnknownNew risk score for predicting progression of membranous nephropathy.
Not available
S-EPMC6368730 | biostudies-literature
UnknownPhase I trial of lenalidomide and CCI-779 in patients with relapsed multiple myeloma: evidence for lenalidomide-CCI-779 interaction via P-glycoprotein.
Not available
S-EPMC3164245 | biostudies-literature
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