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ProteomicsIdentification of cellular CDK9 substrates using an analog-sensitive cell line
Analog-sensitive kinase technology allows for specific inhibition of a given kinase. Here we utilize an analog-sensitive CDK9 cell line to determine the impact of CDK9 inhibition on the phospho-proteome of human cells. Specifically, we aim to identify substrates of CDK9 in a quantitative way using s...
ORGANISM(S): Homo sapiens (Human) 
2019-11-11 | PXD014825 | Pride
Analog-sensitive Mass spectrometry P-tefb Protein phosphorylation 
ProteomicsThe innate immunity kinase TAK1 phosphorylates Rab1 on a hotspot for post-translational modifications by host and pathogen
TGF-β Activated Kinase 1 (TAK1) is a critical signaling hub responsible for translating antigen binding signals to immune receptors for the activation of the AP-1 and NF-κB master transcriptional programs. Despite its importance, known substrates of TAK1 are limited to kinases of the MAPK and IKK fa...
ORGANISM(S): Homo sapiens (Human) 
2016-07-19 | PXD004213 | Pride
Kinase Covalent capture Kinase substrates Analog specific kinase 
ProteomicsIdentification of RSK substrates using an analog-sensitive kinase approach
RSK1 and RSK4 are two of the four members of the p90 ribosomal protein S6 kinases (RSK) family. These kinases are downstream kinases of mitogen-activated protein kinase 1 (ERK or MAPK1) in the ERK MAP kinase pathway. RSKs are implicated in fine tuning of cellular processes such as translation, trans...
ORGANISM(S): Homo sapiens (Human) 
2024-02-06 | PXD047020 | Pride
Rsk1 Rsk4 Mapk pathway Kinase Substrate 
TranscriptomicsTranscription profiling of Arabidopsis mkk1, mkk2 and mkk1/2 knockout treated with the saliicylic acid analog BTH
Gene Expression profiling of the Arabidopsis thaliana MAP Kinase Kinases 1 (mkk1), MAP Kinase Kinases 2 (mkk2) knockout mutants and the double mutant mkk1/mkk2 before and 24 hours after treatment with the salicylic acid analog BTH, was measured by hybridisation to an Affymetrix ATH1 GeneChip. Experi...
ORGANISM(S): Arabidopsis thaliana 
2008-06-11 | E-GEOD-10646 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse S49 cells to study the global impact of cAMP and protein kinase A on gene expression
Although a substantial number of hormones and drugs increase cellular cAMP levels, the global impact of cAMP and its major effector mechanism, protein kinase A (PKA), on gene expression is not known. Here we show that treatment of wild-type S49 lymphoma cells for 24 h with 8-(4-chlorophenylthio)-cAM...
ORGANISM(S): Mus musculus 
2007-08-31 | E-GEOD-2413 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human activated T lymphocytes to determine the effects of TX527, a hypocalcemic vitamin D analog
Hypocalcemic vitamin D analogs are appealing molecules to exploit the immunomodulatory actions of active vitamin D in vivo. The functional modulation of dendritic cells is regarded as the key mechanism underlying their ability to regulate T cell responses. In contrast, the direct actions of vitamin ...
ORGANISM(S): Homo sapiens 
2010-11-15 | E-GEOD-23984 | biostudies-arrayexpress
UnknownAn Affinity-Based, Cysteine-Specific ATP Analog for Kinase-Catalyzed Crosslinking.
Not available
S-EPMC8084585 | biostudies-literature
TranscriptomicsGene expression profiling of Activin-like kinase 2 knockout in mice
Implantation of an embryo in the uterus is a multistep process tightly controlled by an intricate regulatory network of interconnected ovarian, uterine, and embryonic factors. Bone morphogenetic protein (BMP) ligands and receptors are expressed in the pregnant uterus, and BMP2 has been shown to be a...
ORGANISM(S): Mus musculus 
2014-01-07 | E-GEOD-46689 | biostudies-arrayexpress
UnknownGeneration and characterization of ATP analog-specific protein kinase Cδ.
Not available
S-EPMC4303651 | biostudies-literature
ProteomicsWith no lysine kinase 1 in hepatic stellate cells promotes mouse and human liver fibrosis through glycolytic triosephosphate isomerase 1
Liver fibrosis and cirrhosis are major global health burdens with limited treatments. Activated hepatic stellate cells (HSCs) drive fibrosis through increased proliferation, migration, collagen deposition and glycolysis. The aim of this study is to elucidate the signaling events that lead to enhance...
ORGANISM(S): Homo sapiens (Human) 
2026-08-13 | PXD078687 | Pride
Liver fibrosis. Chemical genetics Wnk1 Glucose metabolism Tpi1 Hepatic stellate cells 
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