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TranscriptomicsHistone acetylation and DNA demethylation of T-cells result in an anaplastic large cell lymphoma-like phenotype.
A characteristic feature of anaplastic large cell lymphoma (ALCL) is the significant reduction of the T-cell expression program despite its T-cell origin, a finding very similar to the loss of B-cell identity of classical Hodgkin lymphoma (cHL). Previously we demonstrated that epigenetic mechanisms ...
ORGANISM(S): Homo sapiens 
2012-08-19 | E-GEOD-26101 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Breast Implant-Associated Anaplastic Large Cell Lymphoma
Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is an anaplastic lymphoma kinase-negative (ALKneg) T-cell lymphoma. Here, we provide RNA-seq data of four BIA-ALCL and four ALCL cell lines:TLBR-1, TLBR-2, TLBR-3, TLBR-4 and DEL (two replicates), KARPAS-299, KI-JK, SUP-M2 (two repl...
ORGANISM(S): Homo sapiens 
2025-01-14 | E-MTAB-14735 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human large cell anaplastic lymphoma and classical Hodgkin lymphoma
Analysis of differential gene expression in human non-Hodgkin`s lymphoma cell lines and a primary leukaemic tumor sample of large cell anaplastic type in comparison with Hodgkin`s lymphoma cell lines and other non-Hodgkin`s lymphoma samples and non-neoplastic lymphocytes Experiment Overall Design: S...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-4109 | biostudies-arrayexpress
TranscriptomicsMCL1 inhibitor induces apoptosis in Anaplastic Large Cell Lymphoma and in Primary Effusion Lymphoma
Overexpression of antiapoptotic BCL2 family proteins occurs in various hematologic malignanices and contributes to leukemogenesis by inhibiting the apoptotic machinery of the cells. BH3 mimetics provide an option for medication, with venetoclax as the first drug applied for chronic lymphocytic leuke...
ORGANISM(S): Homo sapiens 
2021-12-31 | E-MTAB-10903 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of 32 human Anaplastic Large Cell Lymphomas (ALCL) and 5 ALCL cell lines to investigate differences between tumors expressing/not-expressing Anaplastic Lymphoma kinkase
A "Cartes d'Identite des Tumeurs" (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net). Affymetrix UU133A gene expression data for a series of 32 cases of systemic Anaplastic Large Cell Lymphoma
(ALCL) and 5 ALCL cell lines; used to (1) confirm that tumors...
ORGANISM(S): Homo sapiens 
2007-05-05 | E-TABM-117 | biostudies-arrayexpress
ProteomicsT-cell-derived Hodgkin lymphoma has motility characteristics intermediate between Hodgkin and anaplastic large cell lymphoma
Global proteomics profiling of anaplastic large cell lymphoma cell lines DEL, SU-DHL-1 (ALK+), Mac-1, Mac-2A (ALK-) as well as Hodgkin lymphoma cell lines L-428, L-540, L-1236 and HDLM-2.
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD031907 | Pride
Cell motility Global proteome Anaplastic large cell lymphoma Hodgkin lymphoma 
TranscriptomicsTranscription profiling of human anaplastic large cell lymphoma cell lines - kinase signature
Anaplastic Large Cell Lymphomas (ALCL) represent a subset of lymphomas in which the Anaplastic Lymphoma Kinase (ALK) gene is frequently fused to the NPM gene. We previously demonstrated that the constitutive phosphorylation of ALK chimeric proteins is sufficient to induce cellular transformation in ...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6184 | biostudies-arrayexpress
TranscriptomicsEssential role of IRF4 and MYC signaling for survival of anaplastic large cell lymphoma survival
Three ALCL cell lines DEL, FEPD and K299 were induced with an IRF4-specific shRNA for up to 96 hours. The three ALCL cell lines DEL, FEPD and K299 were induced with an IRF4-specific shRNA for four durations and compared with the corresponding not-induced control.
ORGANISM(S): Homo sapiens 
2015-01-03 | E-GEOD-59747 | biostudies-arrayexpress
ProteomicsDissection of acetylomic profiles in T cell lymphoma following histone deacetylases inhibition
The aim was to dissect molecular changes in histone and non-histone protein acetylation dynamics following the genetic or pharmacological inhibition of HDAC activity in a model of Anaplastic Large Cell Lymphoma (ALCL), a T cell non-Hodgkin lymphoma, predominantly found in children and adolescents.
ORGANISM(S): Mus musculus (Mouse) 
2022-10-14 | PXD030503 | Pride
Acetylomics Histone deacetylase inhibitors Anaplastic large cell lymphoma Histone deacetylases Proteomics 
TranscriptomicsIdentification of C/EBPβ Target Genes in ALK+ Anaplastic Large Cell Lymphoma (ALCL) by Gene Expression Profiling and Chromatin Immunoprecipitation
C/EBPβ (CCAAT enhancer binding protein) is a transcription factor that plays a crucial role in survival and transformation of ALK+ anaplastic large cell lymphoma (ALCL). The aim of this study was to identify the downstream targets of C/EBPβ responsible for ALK-mediated oncogenesis. C/EBPβ was knocke...
ORGANISM(S): Homo sapiens 
2013-07-10 | E-GEOD-23368 | biostudies-arrayexpress
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