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MetabolomicsAn ancient residue metabolomics-based method to distinguish use of closely related plant species in ancient pipes

Residues from ancient artifacts can help identify which plant species were used for their psychoactive properties, providing important information regarding the deep-time co-evolutionary relationship between plants and humans. However, relying on the presence or absence of one or several biomarke...

2020-07-21 | MTBLS890 | MetaboLights
MetabolomicsMolecular profiling of sponge movement reveals an ancient contractile-inflammatory response

A hallmark of animals is the coordination of whole-body movement. Neurons and muscles are central to this; yet, coordinated movements also exist in sponges that lack these cell types. Sponges are sessile animals with a complex canal system for filter-feeding. They undergo whole-body movements res...

2026-08-11 | MTBLS8137 | MetaboLights
MetabolomicsMetabolomics profiling reveals changes in peptidoglycan and redox metabolism between ancient and modern Mycobacterium tuberculosis

Mycobacterium tuberculosis (Mtb), the cause of tuberculosis, kills over one million people worldwide each year. Mtb is classified into ten distinct lineages, each harboring unique genetic changes that influence its survival, virulence, and transmissibility. Although metabolism plays a cr...

2026-06-26 | MTBLS14029 | MetaboLights
MetabolomicsEvolution of diapause in the African killifish by remodeling ancient gene regulatory landscape
Not available
ORGANISM(S): Nothobranchius furzeri;Aphyosemion striatum 
ST001898 | MetabolomicsWorkbench
ProteomicsProtein Extraction from Ancient Teeth and Dental Calculus Compatible with Subsequent DNA Extraction
Dental calculus is becoming a crucial material in the study of past populations, with increasing interest in its proteomic and genomic content. Here we suggest further development of protocol for analysis of ancient proteins and a combined approach for subsequent ancient DNA extraction. We tested th...
ORGANISM(S): Homo sapiens (Human) 
2023-09-11 | PXD042668 | Pride
Protein extraction Palaeoproteomics Ancient dna Ancient proteins Dental calculus Bioarchaeology 
GenomicsExtensive conservation of ancient microsynteny across metazoans
Gene order, or microsynteny, is generally thought not to be conserved across metazoan phyla. Only a handful of exceptions, typically of tandemly duplicated genes such as Hox genes, have been discovered. Here, we performed a systematic survey for microsynteny conservation in 17 genomes and identified...
ORGANISM(S): Danio rerio 
2012-06-21 | E-GEOD-35050 | biostudies-arrayexpress
ProteomicsAncient tooth enamel proteomes to help understand post mortem protein degradation over millions of years
The tooth enamel proteome is enzymatically broken down during development, which leads to a heterogenous distribution of remaining peptides of a protein sequence in a grown individual's enamelome. After death of the organism, the heterogeneous distribution of remaining peptides may be enhanced, as t...
ORGANISM(S): Equidae Proboscidea <placentals> 
2025-05-06 | PXD048972 | Pride
Proboscidea Paleoproteomics Equidae Ancient Enamel 
ProteomicsDairying enabled Early Bronze Age Yamnaya steppe expansions
Ancient protein analysis of human dental calculus to look for evidence of early milk consumption
ORGANISM(S): Homo sapiens (Human) 
2021-08-09 | PXD022300 | Pride
Dairy Pontic caspian region Steppe Ancient proteins Pastoralism 
TranscriptomicsThe Caucasus as an asymmetric semipermeable barrier to ancient human migrations
The Caucasus, inhabited by modern humans since the Early Upper Paleolithic and known for its linguistic diversity, is considered to be important for understanding human dispersals and genetic diversity in Eurasia. We report a synthesis of autosomal, Y chromosome, and mitochondrial DNA (mtDNA) variat...
ORGANISM(S): Homo sapiens 
2012-04-17 | E-GEOD-37342 | biostudies-arrayexpress
ProteomicsProteomic Analysis Reveals Protein Degradation in Waterlogged Ancient Leather
Leather artifacts hold significant historical and cultural value in human civilization. During long-term preservation, ancient relics, especially waterlogged leather artifacts, are susceptible to protein degradation. Therefore, analyses of the structure and protein composition of these ancient relic...
ORGANISM(S): Bos Taurus 
2025-03-10 | PXD061671 |
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