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MetabolomicsMolecular profiling of sponge movement reveals an ancient contractile-inflammatory response

A hallmark of animals is the coordination of whole-body movement. Neurons and muscles are central to this; yet, coordinated movements also exist in sponges that lack these cell types. Sponges are sessile animals with a complex canal system for filter-feeding. They undergo whole-body movements res...

2026-08-11 | MTBLS8137 | MetaboLights
MetabolomicsFaecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity- and neurotransmission-related proteins in young recipients

BACKGROUND: The gut-brain axis and the intestinal microbiota are emerging as key players in health and disease. Shifts in intestinal microbiota composition affect a variety of systems, however, evidence of their direct impact on cognitive functions is still lacking. We tested whe...

2021-12-17 | MTBLS1437 | MetaboLights
ProteomicsProtein Extraction from Ancient Teeth and Dental Calculus Compatible with Subsequent DNA Extraction
Dental calculus is becoming a crucial material in the study of past populations, with increasing interest in its proteomic and genomic content. Here we suggest further development of protocol for analysis of ancient proteins and a combined approach for subsequent ancient DNA extraction. We tested th...
ORGANISM(S): Homo sapiens (Human) 
2023-09-11 | PXD042668 | Pride
Protein extraction Palaeoproteomics Ancient dna Ancient proteins Dental calculus Bioarchaeology 
ProteomicsAncient proteins resolve controversy over the identity of Genyornis eggshell
Here we show the potential of proteins preserved in Pleistocene eggshell for addressing a longstanding controversy in human and evolution: the identity of the extinct bird that laid the eggs which were exploited by Australia’s first inhabitants. The eggs had been originally attributed to the iconic ...
ORGANISM(S): Galloanserae 
2022-07-19 | PXD027713 | Pride
Genyornis eggshell  australia  palaeoproteomics  ancient dna  megafaunal extinction 
ProteomicsAncient proteins extracted from ceramic residues
Ancient proteins were extracted from ceramic vessels from the West Mound of the key early farming site of Çatalhöyük, dating to the early 6th millennium BC. This analysis revealed that barley, wheat, pulses, as well as goat, sheep and bovinae dairy and meat products were contained in ceramic vessels...
ORGANISM(S): Pisum sativum (Garden pea) Triticum aestivum (Wheat) Hordeum vulgare (Barley) Ovis aries Capra hircus (Goat) 
2018-10-04 | PXD008647 | Pride
Ancient proteins Archaeology Ceramic residues Lc-ms/ms 
ProteomicsProteomic Analysis Reveals Protein Degradation in Waterlogged Ancient Leather
Leather artifacts hold significant historical and cultural value in human civilization. During long-term preservation, ancient relics, especially waterlogged leather artifacts, are susceptible to protein degradation. Therefore, analyses of the structure and protein composition of these ancient relic...
ORGANISM(S): Bos Taurus 
2025-03-10 | PXD061671 |
ProteomicsDairying enabled Early Bronze Age Yamnaya steppe expansions
Ancient protein analysis of human dental calculus to look for evidence of early milk consumption
ORGANISM(S): Homo sapiens (Human) 
2021-08-09 | PXD022300 | Pride
Dairy Pontic caspian region Steppe Ancient proteins Pastoralism 
GenomicsPathogenesis related proteins
Pathogenesis related proteins in ancient Apulian local varieties of legumes
PRJEB21567 | ENA
ProteomicsAncient tooth enamel proteomes to help understand post mortem protein degradation over millions of years
The tooth enamel proteome is enzymatically broken down during development, which leads to a heterogenous distribution of remaining peptides of a protein sequence in a grown individual's enamelome. After death of the organism, the heterogeneous distribution of remaining peptides may be enhanced, as t...
ORGANISM(S): Equidae Proboscidea <placentals> 
2025-05-06 | PXD048972 | Pride
Proboscidea Paleoproteomics Equidae Ancient Enamel 
ProteomicsMilking it? Assessing the degradation of ancient milk proteomes
The origins, prevalence and nature of dairying have been long debated by archaeologists. Within the last decade, new advances in high-resolution mass spectrometry have allowed for the direct detection of milk proteins from archaeological remains, including ceramics, dental calculus, and preserved da...
ORGANISM(S): Homo sapiens (Human) 
2021-08-05 | PXD022368 | Pride
Milk Authentication Palaeoproteomics Deamidation 
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