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ProteomicsSleep deprivation leads to non-adaptive alterations in sleep microarchitecture and amyloid-β accumulation in a murine Alzheimer model
Impaired sleep is a common aspect of aging and often precedes the onset of Alzheimer's disease. Here, we compare the effects of sleep deprivation in young wild-type mice and their APP/PS1 littermates, a murine model of Alzheimer's disease. After 7 h of sleep deprivation, both genotypes exhibit an in...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-30 | PXD054763 | Pride
Proteomics Sleep Extracellular fluid Mouse Cerebrospinal fluid 
ProteomicsA proteome analysis by LC-MS/MS of human colon mucosal biopsies from gastrointestinal healthy rheumatoid arthritis patients
The joint disease rheumatoid arthritis (RA) is characterized by persistent synovitis, leading to cartilage damage, bone erosion, and ultimately impaired joint function. The disease affects 0.5 to 1.0% of adults in developed countries, and is three times more frequent in women than in men. A number o...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080861 | MassIVE
ProteomicsDistinct Impact of Neuronal and Astrocytic IFNAR1 Loss in Parkinson-like Dementia
Interferon-alpha/beta-receptor (IFNAR) signal defects were recently identified to contribute to sporadic Parkinson’s disease (PD) with dementia (PDD). Mice lacking interferon-beta (IFNβ) develop PDD-like disease; however, the phenotypic, cellular, and molecular impacts of IFNAR1 loss in vivo have no...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-08 | PXD037113 | Pride
Ifnar1 Glutamatergic neurotransmission Snrna-seq Parkinson’s disease dementia Lc-ms/ms 
OtherNeutrophil Extracellular Traps in Ulcerative Colitis: A Proteome Analysis of Intestinal Biopsies.
Data from ProteomeXchange, PXD ID: PXD001608. File: UC_2_3.mzml. Ulcerative colitis sample. Published as part of Inflamm Bowel Dis. 2015 May 19 . From the Abstract: {{i}} The etiology of the inflammatory bowel diseases, including ulcerative colitis (UC), remains incompletely explained. We hypothesi...
ORGANISM(S): Homo_sapiens_viruses, Human, Bacteroides_thetaiotaomicron_vpi_5482, Escherichia_coli_k_12_substr__mg1655 
GPM32320015348 | GPMDB
Resource Reanalysis 
ProteomicsHuman colon biopsies (healthy and Ulcerative Colitis) LC-MS/MS
The etiology of the inflammatory bowel diseases, including ulcerative colitis, remains incomplete, but recent findings points to the involvement of complex host-microbial interactions. We hypothesized that an analysis of the proteins on the host-microbial interacting surface, the intestinal mucosa, ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080833 | MassIVE
ProteomicsHippocampal disruptions of synaptic and astrocyte metabolism during early amyloid pathology in the 5xFAD mouse model of Alzheimer’s disease
Alzheimer’s disease (AD) is an unremitting neurodegenerative disorder characterized by cerebral amyloid-β (Aβ) accumulation and gradual decline in cognitive function. Changes in brain energy metabolism arise in the preclinical phase of AD, suggesting an important metabolic component of early AD path...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-09 | PXD025240 | Pride
Synaptosomes Hippocampus Ad Brain energy metabolism Seahorse Mitochondria Glucose Cerebral cortex 
Unknown100 ancient genomes show repeated population turnovers in Neolithic Denmark.
Not available
S-EPMC10781617 | biostudies-literature
UnknownFluid challenges in intensive care: the FENICE study: A global inception cohort study.
Not available
S-EPMC4550653 | biostudies-literature
UnknownTherapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19.
Not available
S-EPMC8362594 | biostudies-literature
UnknownManagement and outcomes in critically ill nonagenarian versus octogenarian patients.
Not available
S-EPMC8524896 | biostudies-literature
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