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TranscriptomicsGene expression analysis between the pancreatic tissues of Pdx1-cre;Kras LSL-G12D and Pdx-cre;KrasLSL-G12D;IKK2/beta F/F mice
Constitutive Kras and NF-kB activation is identified as signature alterations in human pancreatic ductal adenocarcinoma (PDAC). Here, we report that pancreas-targeted IKK2/beta inactivation inhibited NF-kB activation and completely suppressed PDAC development. Our findings demonstrated that NF-kB is...
ORGANISM(S): Mus musculus 
2012-01-24 | E-GEOD-33322 | biostudies-arrayexpress
TranscriptomicsKras-induced ikk2/nf-kappaB activation by IL-1 alpha and p62 freedforward loops is required for development of pancreatic ductal adenocarcinoma
This SuperSeries is composed of the following subset Series: GSE27478: Gene expression differences between the pancreatic tissues of Pdx1-Cre;KrasLSL-G12D and Pdx1-Cre;KrasLSL-G12D;IKK2/betaF/F mice GSE33322: Gene expression analysis between the pancreatic tissues of Pdx1-cre;Kras LSL-G12D and Pdx-c...
ORGANISM(S): Mus musculus 
2012-01-24 | E-GEOD-33323 | biostudies-arrayexpress
UnknownIn Vivo 6-([18F]Fluoroacetamido)-1-hexanoicanilide PET Imaging of Altered Histone Deacetylase Activity in Chemotherapy-Induced Neurotoxicity.
Not available
S-EPMC5884410 | biostudies-literature
UnknownMouse Models of Overexpression Reveal Distinct Oncogenic Roles for Different Type I Protein Arginine Methyltransferases.
Not available
S-EPMC6714580 | biostudies-literature
TranscriptomicsMicroRNA-203 represses selection and expansion of oncogenic HRas transformed tumor initiating cells [seq]
In many mouse models of skin cancer, only a few tumors typically form although many cells competent for tumorigenesis receive the same oncogenic mutations. These observations suggest a selection process for defining tumor initiating cells. Here we use quantitative mRNA- and miR-Seq to determine the ...
ORGANISM(S): Mus musculus 
2015-07-23 | E-GEOD-66054 | biostudies-arrayexpress
UnknownPeritoneal Microenvironment Promotes Appendiceal Adenocarcinoma Growth: A Multi-omics Approach Using Patient-Derived Xenografts.
Not available
S-EPMC10987270 | biostudies-literature
UnknownTime-lapse imaging of the dynamics of CNS glial-axonal interactions in vitro and ex vivo.
Not available
S-EPMC3267745 | biostudies-literature
UnknownDiscovery of selective inhibitors of the Clostridium difficile dehydroquinate dehydratase.
Not available
S-EPMC3931744 | biostudies-literature
UnknownMacrophages direct cancer cells through a LOXL2-mediated metastatic cascade in pancreatic ductal adenocarcinoma.
Not available
S-EPMC9872246 | biostudies-literature
TranscriptomicsTesticular germ cell tumor susceptibility genes from the consomic 129.MOLF-Chr19 mouse strain
Chromosome substitution strains (CSS or consomic strains) are useful for mapping phenotypes to chromosomes. However, huge efforts are needed to identify the gene(s) responsible for the phenotype in the complex context of the chromosome. Here, we report the identification of candidate disease genes...
ORGANISM(S): Mus musculus 
2009-01-13 | E-GEOD-14354 | biostudies-arrayexpress
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