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ProteomicsGlobal protein expression profiles of laboratory isolated mutants of E. coli K12, MG1655
Resistance to the antibiotic mecillinam in Escherichia coli can be conferred by mutations in over 100 genes. In this study we compared the global protein expression levels in a number of mecillinam resistant mutants originating from E. coli MG1655 to the levels in the parental strain.
ORGANISM(S): Escherichia coli 
2019-07-29 | PXD007647 | Pride
Escherichia coli Tmt Q exactive Tandem mass tag Microbiology Antibiotic resistance Orbitrap fusion 
ProteomicsRescue of Escherichia coli auxotrophy by de novo small proteins
Increasing numbers of small proteins with diverse physiological roles are being identified and characterized in both prokaryotic and eukaryotic systems, but the origins and evolution of these proteins remain unclear. Recent genomic sequence analyses in several organisms suggest that new functions en...
ORGANISM(S): Escherichia coli 
2023-03-31 | PXD040161 | Pride
Escherichia coli Rna-binding De novo gene evolution Gene regulation His operon Auxotroph Small proteins 
ProteomicsA bacteriophage enzyme induces bacterial metabolic perturbation that confers a novel promiscuous function
One key concept in the evolution of new functions is the ability of enzymes to perform promiscuous side-reactions that serve as a source of novelty that may become beneficial under certain conditions. Here, we identify a mechanism where a bacteriophage-encoded enzyme introduces novelty by inducing e...
ORGANISM(S): Escherichia coli 
2018-05-11 | PXD005236 | Pride
Tmt Escherichia coli Antibiotic resistance Orbitrap fusion 
ProteomicsAddition of RND1 peptide to E. coli BW25113 DELserB, his operator to lacZ transcription fusion.
Addition of RND1 peptide to E. coli BW25113 (DELserB, his operator to lacZ transcription fusion.
ORGANISM(S): Escherichia coli Bacteria 
2022-03-31 | PXD014049 | Pride
Lfq Orbitrap E. coli 
TranscriptomicsGene Copy Number Aberrations are Associated with Survival in Histological Subgroups of Non-Small Cell Lung Cancer (copy number data)
Hypothesis: Non-small cell lung cancer (NSCLC) is characterized by a multitude of genetic aberrations with unknown clinical impact. In this study, we aimed to identify gene copy number changes that correlate with clinical outcome in NSCLC. To maximize the chance to identify clinically relevant event...
ORGANISM(S): Homo sapiens 
2011-11-01 | E-GEOD-28572 | biostudies-arrayexpress
GenomicsGlioma GWAS summary statistics
Meta-analysis association statistics from case-control analysis (includes imputed SNPs)
EGAD00010001657 | EGA
GenomicsSummary statistics from genome-wide association study in glioma of 12,488 cases and 18,169 controls.
Genome-wide association studies (GWAS) have transformed our understanding of glioma susceptibility, but individual studies have had limited power to identify risk loci. We performed a meta-analysis of existing GWAS and two new GWAS, which totaled 12,488 cases and 18,169 controls. We identified five ...
EGAS00001003372 | EGA
GenomicsGlioma GWAS summary statistics DAC
Data Access Committee EGAC00001001116
EGAC00001001116 | EGA
UnknownGenome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors.
Not available
S-EPMC5558246 | biostudies-literature
UnknownStatus of Sepsis Care in European Hospitals: Results from an International Cross-Sectional Survey.
Not available
S-EPMC12005017 | biostudies-literature
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