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TranscriptomicsMML-1/Mondo complexes regulate HLH-30/TFEB via TOR inhibition to promote longevity in response to signals from the reproductive system
Comprehensive transcriptome analysis of hlh-30, mml-1 and mxl-2 in N2 (wildtype) and glp-1 background.
ORGANISM(S): Caenorhabditis elegans 
2016-03-21 | E-MTAB-3686 | biostudies-arrayexpress
Proteomicsmir-1 coordinately regulates lysosomal v-ATPase and biogenesis to affect muscle contractility upon proteotoxic challenge during ageing
Muscle function relies on the precise architecture of dynamic contractile elements, which must be fine-tuned to maintain motility throughout life. Muscle is also highly plastic, and remodeled in response to stress, growth, neural and metabolic inputs. The evolutionarily conserved muscle microRNA, mi...
ORGANISM(S): Caenorhabditis elegans 
2021-07-14 | PXD023544 | Pride
Lfq Worm 
ProteomicsNFYB-1 regulates mitochondrial function and longevity via lysosomal prosaposin
Mitochondrial activity is critical for cellular vitality and organismal longevity, yet underlying regulatory mechanisms spanning these different levels of organization remain elusive. From RNAi screens for mitochondrial biogenesis, we discovered NFYB-1, a subunit of the NF-Y transcriptional complex,...
ORGANISM(S): Caenorhabditis elegans 
2020-03-11 | PXD013233 | Pride
Nfyb-1 Mitochondria Proteomics Ceramide Metabolomics Cardiolipin Single shot Stress response Prosaposin Ageing Label-free Transcriptomics 
TranscriptomicsComparison of gene expression profiles between N2 wild-type C. elegans and an nhr-8(hd117) mutant
Transcriptional profiling of N2 vs. nhr-8 mutant worms, aiming to identify direct and indirect targets of the nuclear receptor. Seven independent synchronized populations of N2 and nhr-8(hd117) animals were grown from eggs on low cholesterol plates at 25 degrees C until mid-L3 larval stage and colle...
ORGANISM(S): Caenorhabditis elegans 
2013-08-06 | E-GEOD-48675 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of WT and blmp-1(tm548) mutant L3 larvae
We performed RNA-seq analysis of WT and blmp-1(tm548) mutant L3 larvae to identify genes regulated by the zing-finger transcription factor BLMP-1. We analyzed three WT and three blmp-1 mutant biological replicates
ORGANISM(S): Caenorhabditis elegans 
2014-03-11 | E-GEOD-55225 | biostudies-arrayexpress
TranscriptomicsmRNA profile in DR-related mutants
Dietary restriction (DR) extends lifespan in a wide variety of species, yet the underlying mechanisms are not well understood. Here we show that the Caenorhabditis elegans HNF4α-related nuclear hormone receptor NHR-62 is required for metabolic and physiologic responses associated with DR-induced lon...
ORGANISM(S): Caenorhabditis elegans 
2014-03-19 | E-GEOD-55988 | biostudies-arrayexpress
UnknownLoss of killifish cGAS attenuates age-related signatures but does not affect organismal life span
Not available
S-SCDT-10_1038-S44319-026-00917-Y | biostudies-other
UnknownAgeing induces tissue specific transcriptomic changes in Caenorhabditis elegans
Not available
S-SCDT-EMBOJ-2021-109633 | biostudies-other
UnknownMitochondrial translocation of TFEB regulates complex I and inflammation
Not available
S-SCDT-10_1038-S44319-024-00058-0 | biostudies-other
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