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MetabolomicsMetabolomic mechanisms of antimicrobial peptides against Helicobacter pylori

Metabolomic mechanisms of antimicrobial peptides against Helicobacter pylori. By establishing treatment and control models combined with untargeted metabolomic analysis, this study aims to reveal the key metabolic pathway alterations and metabolic network reprogramming induced by antimicrobial pe...

2026-02-10 | MTBLS13884 | MetaboLights
MetabolomicsApplication of the Protease-Resistant Antimicrobial Peptide R7I, Composed of Natural Amino Acids, as a Functional Food Ingredient for Modulating Intestinal Health

Foodborne pathogenic bacterial infections pose significant challenges to global food safety and public health, while the issue of antimicrobial resistance (AMR) has worsened in recent years, creating an urgent need for safe, natural alternatives to combat foodborne pathogens and associated intest...

2025-11-09 | MTBLS13292 | MetaboLights
TranscriptomicsThe antimicrobial peptide-sensing system aps of Staphylococcus aureus
Staphylococcus aureus is a leading cause of hospital-associated infections. In addition, highly virulent strains of methicillin-resistant S. aureus (MRSA) are currently spreading outside health care settings. Survival in the human host is largely defined by the ability of S. aureus to resist mechani...
ORGANISM(S): Staphylococcus aureus 
2008-04-06 | E-GEOD-8400 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of E. coli NCTC 9001 challenged with four different cationic antimicrobial peptides
Obtaining an in depth understanding of the arms races between peptides comprising the innate immune response and bacterial pathogens is of fundamental interest and will inform the development of new antibacterial therapeutics. Many cationic antimicrobial peptides (AMPs) share a range of structural a...
ORGANISM(S): Escherichia coli 
2014-01-21 | E-MTAB-1703 | biostudies-arrayexpress
TranscriptomicsA Gram-positive three-component antimicrobial peptide-sensing system
To survive during colonization or infection of the human body, microorganisms must defeat antimicrobial peptides, which represent a key component of innate host defense in phagocytes and on epithelia. However, is not known how the clinically important group of Gram-positive bacteria sense antimicrob...
ORGANISM(S): Staphylococcus epidermidis 
2010-05-26 | E-GEOD-7163 | biostudies-arrayexpress
ProteomicsDiscovery of Novel Antimicrobial Peptides from Varanus komodoensis (Komodo dragon) by Large Scale Analyses and De Novo Assisted Sequencing using Electron Transfer Dissociation Mass Spectrometry
We have employed a custom bioprospecing approach to identify cationic antimicrobial peptides from Komodo dragon plasma. Through these analyses we identified forty eight novel potential cationic antimicrobial peptides, with all but one of the identified peptides being derived from histone proteins. T...
ORGANISM(S): Varanus komodoensis 
2017-02-08 | PXD005043 | Pride
Ms/ms Plasma Etd Komodo Antimicrobial peptides 
ProteomicsMarine-inspired antimicrobial peptides disrupt gene expression on DNA level
Genome mining of Streptomyces sp. H-KF8 combined with sequence engineering yielded two serum-stable, non-cytotoxic, non-lytic antimicrobial peptides, L3 and L3-K. Initial studies in uropathogenic Escherichia coli suggested membrane effects and nucleoid relaxation, prompting a comprehensive investiga...
ORGANISM(S): Escherichia coli 
2026-01-23 | PXD068455 | Pride
Antimicrobial peptides  global proteomics  tmt 
TranscriptomicsResponses of S. aureus to stress caused by sublethal concentration of cationic antimicrobial peptides
Understanding how pathogens respond to antimicrobial peptides, and how this compares to currently available antibiotics, is crucial to optimizing antibiotic therapy. Staphylococcus aureus has several known resistance mechanisms against human cationic antimicrobial peptides (CAMPs). We aim to determi...
ORGANISM(S): Staphylococcus aureus 
2010-03-01 | E-GEOD-15800 | biostudies-arrayexpress
ProteomicsDiversity of cationic antimicrobial peptides in black cumin (Nigella sativa L.) seeds
Black cumin (Nigella sativa L.) is known to possess a wide variety of antimicrobial peptides belonging to different structural families. Three novel antimicrobial peptides have been isolated from black cumin seeds. Two of them were attributed as members of the non-specific lipid transfer proteins fa...
ORGANISM(S): Nigella sativa 
2023-07-20 | PXD040611 | Pride
Defensin Lipid transfer protein (ltp) Antimicrobial peptide (amps) Proteomic analysis Antimicrobial activity 
MetabolomicsProteolytic-Resistant Self-Assembling Peptide Nanofibers Combat Specific Bacterial Infections via Trap-and-Kill

The rise in global antibiotic resistance highlights the urgent need for effective antimicrobial agents. Antimicrobial peptides (AMPs) offer a potential solution to combat bacterial resistance. However, key challenges remain in addressing the limitations of current peptide drugs and biomaterials, ...

2025-06-13 | MTBLS12424 | MetaboLights
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