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MetabolomicsGlutamine-restricted diets restore sensitivity to KRASG12D inhibitor through the reversal of ANXA1-mediated metabolic reprogramming
This study investigates the mechanisms underlying KRASG12D inhibitor resistance and evaluates strategies to enhance treatment sensitivity. Our findings indicate that a glutamine-restricted diet not only reverses KRASG12D inhibitor resistance in PDAC but also achieves durable remission with long-term...
2026-06-27 | MTBLS14825 | MetaboLights
TranscriptomicsmiRNA expression data from MCF-7 cells, overexpressing ANXA1
Annexin 1 (ANXA1), an endogenous anti-inflammatory protein which modulates cellular processes such as proliferation, differentiation and apoptosis has been implicated in cancer initiation and progression. ANXA1 was previously shown to be regulated by hsa-miR-196a and promoted cell proliferation and...
ORGANISM(S): Homo sapiens 
2015-01-05 | E-GEOD-54439 | biostudies-arrayexpress
ProteomicsTime-resolved analysis of proteolytic products of ANXA1 by recombinant HTRA1
A proteolytic cleavage experiment was performed with the recombinant unfolded protein Annexin A1 (ANXA1) and recombinant HTRA1_∆mac protease, to identify cleavage sites in ANXA1. In this experiment, unfolded and denatured ANXA1 was used to compare the cleavage sites that are cleaved efficiently and ...
ORGANISM(S): Homo sapiens (Human) 
2024-09-20 | PXD031534 | Pride
Anxa1 Cleavage Mass spectrometry Htra1 
GenomicsAnxA1 inhibits pathological bone resorption
AnxA1 inhibits pathological bone resorption
PRJNA759264 | ENA
ProteomicsIdentification of ANXA1 as A Novel Upstream Negative Regulator of Notch1 Function in AML
Abnormal Notch1 expression has an important role in tumorigenesis. However, upstream control mechanisms for Notch1 are still insufficiently understood. Acute myeloid leukemia (AML) is one of the most common and lethal blood malignancies with limited possibilities for treatment. Thus, new therapeutic...
ORGANISM(S): Homo Sapiens 
PXD056593 |
GenomicsAbsence of Anxa1 in myeloid lineage cells exacerbates acute pancreatitis (AP)
Absence of Anxa1 in myeloid lineage cells exacerbates acute pancreatitis (AP)
PRJNA1050229 | ENA
ProteomicsANXA1 promotes tumor immune evasion by binding PARP1 and upregulating the transcription of PD-L1 in the multiple cancers
To search proteins that interact with ANXA1, ANXA1 interactors were coimmunoprecipitated with anti-ANXA1 antibody from MB231 cell extracts, separated on SDS-PAGE and stained with Coomassie blue , and non-immune IgG antibody instead of anti-ANXA1 antibody served as control. All bands were excised, an...
ORGANISM(S): Homo Sapiens 
PXD036235 |
GenomicsThe cell-intrinsic role of ANXA1 in human ILC2s
The cell-intrinsic role of ANXA1 in human ILC2s
PRJNA875883 | ENA
TranscriptomicsmiR-196a is able to restore the aggressive phenotype of Annexin A1 CRISPR/Cas9 knock-out pancreatic cancer cells
Annexin A1 (ANXA1) is a Ca2+-binding protein involved in pancreatic cancer (PC) progression. It is able to mediate cytoskeletal organization maintaining a malignant phenotype. ANXA1 Knock-Out (KO) MIA PaCa-2 cells partially lost their migratory and invasive capabilities and also the metastatization ...
ORGANISM(S): Homo sapiens 
2018-08-31 | E-MTAB-6599 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human breast cancer cell line BT-474 with annexin A1 over-expression or silenced with siRNA to demonstrate design of multi-condition experiments
Multiple-condition experiment was desinged to be any number of conditions in an experiment without replicate observations for microarray and used to identify genes differentially expressed between different pairs of conditions (treatments).
In this study we used breast cancer stable cell lines f...
ORGANISM(S): Homo sapiens 
2010-06-26 | E-MEXP-2775 | biostudies-arrayexpress
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