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ProteomicsIdentification of novel biomarkers for aortic aneurysm
To discover novel biomarkers for aortic aneurysm, serum samples of patients with thoracic aortic aneurysm were fractionated, tryptic digested, and subjected to proteome analysis.
ORGANISM(S): Homo Sapiens (human) 
2023-11-15 | PXD033774 | JPOST Repository
TranscriptomicsTranscription profiling of human patients with aortic aneurysms associated with tricuspid and bicuspid valves
Patients with bicuspid aortic valve (BAV) have increased risk of thoracic ascending aortic aneurysm (AscAA) and dissection compared to those with a normal tricuspid aortic valve (TAV). The present study was undertaken to evaluate whether differences in gene expression exist in aortas from BAV and TA...
ORGANISM(S): Homo sapiens 
2009-02-07 | E-GEOD-5180 | biostudies-arrayexpress
GenomicsExpression data from control, aortic aneurysm, and aortic dissection cells
Expression data from control, aortic aneurysm, and aortic dissection cells
PRJNA907394 | ENA
ProteomicsCDKL1 risk variants predispose to a connective tissue disorder with thoracic aortic aneurysm and dissection
Genetic factors are fundamental in the etiology of thoracic aortic aneurysm and dissection (TAAD), but the genetic cause is detected in only about 30% of cases. To define unreported TAAD-associated sequence variants, exome and gene panel sequencing was performed in 323 patients. We identified hetero...
ORGANISM(S): Homo sapiens (Human) 
2025-09-09 | PXD048044 | Pride
Cdkl1 Cgmp signaling Thoracic aortic aneurysm and dissection Arterial aneurysm and dissection Hereditary aortopathy Connective tissue disorder 
ProteomicsUnderstanding the role of TGFbeta signaling on aortic aneurysm and rupture using Marfan syndrome mouse models
Although abnormal TGFbeta signaling is observed in several heritable forms of thoracic aortic aneurysms and dissections including Marfan syndrome, the precise role of TGFbeta signaling in aortic disease progression is still disputed. Using a mouse genetic approach and quantitative isobaric labeling ...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-09 | PXD036222 | Pride
Mouse models Marfan syndrome Psr-ohsu Tgfbeta signaling Fibrillin Quantitative proteomics Aortic aneurysm and dissection Tandem mass tags 
TranscriptomicsAdvanced Study of Aortic Pathology (ASAP)
BACKGROUND: The vast majority of thoracic aortic aneurysms (TAAs) are observed either together with a bicuspid aortic valve (BAV), a common congenital disorder, or in idiopathic cases such as patients with a normal tricuspid aortic valve (TAV). The main objective of our study was to identify shared ...
ORGANISM(S): Homo sapiens 
2016-01-15 | E-GEOD-26155 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of aorta from mice underexpressing Fibulin-4 to investigate its role in elastic fibre assembly and cardio-vasuclar disease
Extracellular elastic fibres apply structure and mechanical elasticity to organs such as large arteries, lungs and skin 1. Elastic fibres are assembled through polymerization of tropoelastin monomers and loss of elastin is associated with aneurysmal degeneration of the aorta 2. The Fibulins are a ...
ORGANISM(S): Mus musculus 
2007-01-01 | E-MEXP-840 | biostudies-arrayexpress
TranscriptomicsTranscriptional profile of monocytes under high glucose in Stanford A acute aortic dissection
Hyperglycemia, a common transient metabolic disturbance, is strongly associated with postoperative complications, yet the underlying immunometabolic mechanisms remain poorly understood. To investigate the impact of high glucose on monocytes in Stanford type A acute aortic dissection (ATAAD), we perf...
ORGANISM(S): Homo sapiens 
2025-12-01 | E-MTAB-16247 | biostudies-arrayexpress
ProteomicsAging aggravates aortic aneurysm and dissection via the miR-1204-MYLK signaling axis
The mechanism by which aging induces aortic aneurysm and dissection (AAD) remains unclear. A total of 430 subjects were recruited for screening of differentially expressed plasma microRNAs. We found that miR-1204 was significantly increased in both plasma and aorta of elder patients with AAD, and w...
ORGANISM(S): Homo sapiens (Human) 
2024-04-01 | PXD048658 | Pride
Aortic aneurysm and dissection  aging  senescence-associated secretory phenotype  microrna  myosin light chain kinase 
GenomicsIntegrin αV as a potential target in aortic aneurysm and dissection
Integrin αV as a potential target in aortic aneurysm and dissection
PRJNA1096678 | ENA
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