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MetabolomicsExhaustive analysis of endogenous oxPCs in APAP-treated mice.
Not available
ORGANISM(S): Mus musculus 
ST001830 | MetabolomicsWorkbench
TranscriptomicsTranscription profiling of rat blood and liver exposed to acetaminophen (APAP)
This SuperSeries is composed of the following subset Series:; GSE5593: Acetaminophen (APAP) Rat Blood Training Gene Expression Data Set; GSE5594: Acetaminophen (APAP) Rat Blood Test Gene Expression Data Set; GSE5595: Acetaminophen (APAP) Rat Liver Test Gene Expression Data Set; The Supplementary fil...
ORGANISM(S): Rattus norvegicus 
2008-06-14 | E-GEOD-5652 | biostudies-arrayexpress
GenomicsRNAseq on APAP, APAP+MSC, APAP+HDF at 24h
RNAseq on APAP, APAP+MSC, APAP+HDF at 24h
PRJNA814326 | ENA
Transcriptomicsp53 Contributes to Differentiating Gene Expression Following Exposure to Acetaminophen and Its Less Hepatotoxic Regioisomer Both In Vitro and In Vivo
The goal of the present study was to compare hepatic toxicogenomic signatures across in vitro and in vivo mouse models following exposure to acetaminophen (APAP) or its relatively nontoxic regioisomer 3'-hydroxyacetanilide (AMAP). Two different Affymetrix microarray platforms and one Agilent Oligonu...
ORGANISM(S): Mus musculus 
2016-03-29 | E-GEOD-56576 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat blood after exposure to acetaminophen (APAP) - dose response
Gene expression training data set from rat blood samples exposed to either 150, 1500 or 2500 mg/kg of APAP for 6, 12 or 24 hours. Experiment Overall Design: Male F344/N rats, 10-12 weeks old, were exposed to 0 (vehicle only), 150, 1500 or 2500 mg/kg APAP in 0.5% ethyl cellulose by oral gavage in tw...
ORGANISM(S): Rattus norvegicus 
2008-06-14 | E-GEOD-5593 | biostudies-arrayexpress
TranscriptomicsDifferential Regulation of Mitogen-Activated Protein Kinases by Acetaminophen in TAMH cells
Acetaminophen (APAP), a widely used analgesic and antipyretic that is considered to be relatively safe at recommended doses, is the leading cause of drug-induced liver failure in the United States. 3M-bM-^@M-^Y-Hydroxyacetanilide (AMAP), a regioisomer of acetaminophen is useful as a comparative too...
ORGANISM(S): Mus musculus 
2010-07-06 | E-GEOD-18614 | biostudies-arrayexpress
ProteomicsNon-canonical BIM-regulated energy metabolism determines drug-induced liver necrosis
Paracetamol (acetaminophen, APAP) overdose severely damages mitochondria and triggers several apoptotic processes in hepatocytes, but the final outcome is fulminant necrotic cell death, resulting in acute liver failure and mortality. Here, we studied this switch of cell death modes and demonstrate a...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-24 | PXD045034 | Pride
Apap Hepatotoxicity Paracetamol Necrosis 
TranscriptomicsTranscription profiling of male F344/N rats treated with APAP (time series)
Gene expression test data set from rat liver samples exposed to either 150, 1500 or 2000 mg/kg of APAP for 3, 6 or 24 hours. The Supplementary file (appended below) contains the mapping for the decoding of blinded samples. Experiment Overall Design: Male F344/N rats, 10-12 weeks old, were exposed to...
ORGANISM(S): Rattus norvegicus 
2008-06-14 | E-GEOD-5595 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of male F344/N rats blood cells expoxed to APAP, time series
Gene expression test data set from rat blood samples exposed to either 150, 1500 or 2000 mg/kg of APAP for 3, 6 or 24 hours. The Supplementary file (appended below) contains the mapping for the decoding of blinded samples. Experiment Overall Design: Male F344/N rats, 10-12 weeks old, were exposed to...
ORGANISM(S): Rattus norvegicus 
2008-06-14 | E-GEOD-5594 | biostudies-arrayexpress
TranscriptomicsDiscover preclinical biomarkers of hepatotoxicity: Acetaminophen and Carbon tetrachloride
Preclinical biomarkers useful for identification of idiosyncratic drugs have not been identified. It is hypothesized that patterns of transcript expression for the hepatotoxicants, including classical and idiosyncratic hepatotoxicants, are similar and the patterns differ from those of non-hepatotox...
ORGANISM(S): Rattus norvegicus 
2012-03-15 | E-GEOD-32891 | biostudies-arrayexpress
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