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MetabolomicsThe Toxoplasma monocarboxylate transporters are involved in the metabolism within the apicoplast and are linked to parasite survival

The apicoplast is a four-membrane plastid found in the apicomplexans, which harbors biosynthesis and organelle housekeeping activities in the matrix. However, the mechanism driving the flux of metabolites, in and out, remains unknown. Here we used TurboID and genome engineering to identify apicop...

2024-01-15 | MTBLS7060 | MetaboLights
TranscriptomicsTetracyclines Specifically Target the Apicoplast of the Malaria Parasite Plasmodium falciparum
Tetracyclines are effective but slow-acting antimalarial drugs whose mechanism of action remains uncertain. To characterize the antimalarial mechanism of tetracyclines, we evaluated their stage-specific activities, impacts on parasite transcription, and effects on two predicted organelle targets, th...
ORGANISM(S): Plasmodium falciparum 
2010-07-01 | E-GEOD-5267 | biostudies-arrayexpress
ProteomicsAn Essential Factor for Apicoplast Fission and Inheritance in Malaria Parasites
Blood-stage Plasmodium falciparum parasites rely on a non-photosynthetic plastid, the apicoplast, for survival, making it an attractive target for antimalarial intervention. Like the mitochondrion, the apicoplast cannot be generated de novo and must be inherited by daughter parasites during cell div...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2025-10-27 | PXD062126 | Pride
Plasmodium falciparum Mitochondrial fission Pfanchor Apicoplast Gtpase Dynamin adaptor protein 
ProteomicsA dedicated partitioning machinery ensures faithful inheritance of the apicoplast in T. gondii
The tachyzoite stage of the apicomplexan parasite Toxoplasma gondii divides by an internal budding process called endodyogeny. Single copy organelles like the apicoplast, Golgi, and the mitochondrion require a precise machinery to ensure that each daughter cell receives exactly one organelle. The T....
ORGANISM(S): Toxoplasma gondii RH 
2026-08-27 | PXD075456 | Pride
Proximity biotinylation Apicoplast T. gondii 
ProteomicsMetabolisme of artemisinin-resistant falciparum malaria parasites: are apicoplast and mitochondrion pathways key targets?
In the context of artemisinin resistance, the objective of the project was to evaluate the role of apicoplast and mitochondrion pathways during the parasite quiescent state induced by dihydroartemisinin (DHA) treatment. We analysed the proteome of artemisinin-resistant parasites in two conditions: a...
ORGANISM(S): Plasmodium falciparum 
2025-05-06 | PXD048354 | Pride
Artemisinin resistance  metabolism  apicoplast  mitochondrion  quiescence 
GenomicsA mevalonate bypass system facilitates elucidation of apicoplast biology in malaria parasites
A mevalonate bypass system facilitates elucidation of apicoplast biology in malaria parasites
PRJNA561421 | ENA
TranscriptomicsTetracyclines Specifically Target the Apicoplast of the Malaria Parasite Plasmodium falciparum
Tetracyclines are effective but slow-acting antimalarial drugs whose mechanism of action remains uncertain. To characterize the antimalarial mechanism of tetracyclines, we evaluated their stage-specific activities, impacts on parasite transcription, and effects on two predicted organelle targets, th...
ORGANISM(S): Plasmodium falciparum Saccharomyces cerevisiae 
2006-07-11 | GSE5267 | GEO
TranscriptomicsA mevalonate bypass system facilitates elucidation of apicoplast biology in malaria parasites
Malaria parasites rely on a plastid organelle for survival during the blood stages of infection. However, the entire organelle is dispensable as long as the isoprenoid precursor isopentenyl pyrophosphate (IPP) is supplemented in the culture medium. We engineered parasites to produce isoprenoid precu...
ORGANISM(S): Plasmodium falciparum 
2020-02-11 | GSE136169 | GEO
TranscriptomicsThe NTP Generating Activity of Pyruvate Kinase II is Critical for Apicoplast Maintenance in Plasmodium falciparum
The apicoplast of Plasmodium falciparum parasites is believed to rely on the import of three-carbon phosphate compounds for use in organelle anabolic pathways, in addition to the generation of energy and reducing power within the organelle. We generated a series of genetic deletions in an apicoplast...
ORGANISM(S): Plasmodium falciparum 
2020-07-31 | GSE136688 | GEO
ProteomicsDyn2 IP mass spectrometry dataset
Dyn2 IPs performed at Drexel and USF proteomics facility for "An Essential Adaptor for Apicoplast Fission and Inheritance in Malaria Parasites" paper. Associated with the additional dataset PXD062126.
ORGANISM(S): Plasmodium Falciparum (ncbitaxon:5833) 
MSV000099148 | MassIVE
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