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ProteomicsReduced binding of apolipoprotein E4 isoform to complement factor H promotes amyloid-beta induced neuroinflammation
Brain total lysate from ad patient. Reduced binding of apolipoprotein E4 isoform to complement factor H promotes amyloid-beta induced neuroinflammation.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-12-27 | MSV000088618 | MassIVE
GenomicsPeripheral immunomodulatory effects of Apolipoprotein E4 on Alzheimer's disease - Immune Enrichment
Peripheral immunomodulatory effects of Apolipoprotein E4 on Alzheimer's disease - Immune Enrichment
PRJNA947632 | ENA
ProteomicsAlzheimer’s disease risk and the isoform dependence of phospholipid-apolipoprotein E interaction
The ε4 allele of the APOE gene, encoding the E4 isoform of apolipoprotein E, is the leading genetic risk factor for late-onset Alzheimer’s disease. While many potential mechanisms have been proposed to explain this risk, no dominant or unifying process has yet emerged. Here, we explore the primary f...
ORGANISM(S): Homo sapiens (Human) 
2026-03-09 | PXD068681 | Pride
Csp Proteomics Ms Apoe Lipids Plasmalogen 
UnknownApolipoprotein E4 genotype compromises brain exosome production.
Not available
S-EPMC6308312 | biostudies-literature
TranscriptomicsPeripheral immunomodulatory effects of Apolipoprotein E4 on Alzheimer's disease - Immune Enrichment
Apolipoprotein E (APOE) is a lipid and cholesterol transport molecule known to influence Alzheimer's disease (AD) risk in an isoform-specific manner. In particular, the APOE E4 allele is the largest genetic risk factor for late-onset sporadic AD. Our recent findings uncovered activated, clonally exp...
ORGANISM(S): Homo sapiens 
2024-03-22 | GSE227991 | GEO
GenomicsIn Vivo Chimeric Alzheimer’s Disease Modeling of Apolipoprotein E4 Toxicity in Human Neurons
In Vivo Chimeric Alzheimer’s Disease Modeling of Apolipoprotein E4 Toxicity in Human Neurons
PRJNA640668 | ENA
UnknownApolipoprotein E4 Alters Astrocyte Fatty Acid Metabolism and Lipid Droplet Formation.
Not available
S-EPMC6406677 | biostudies-literature
UnknownApolipoprotein E4 is associated with improved cognitive function in Amazonian forager-horticulturalists with a high parasite burden.
Not available
S-EPMC5349792 | biostudies-literature
UnknownApolipoprotein E4 mediates insulin resistance-associated cerebrovascular dysfunction and the post-prandial response.
Not available
S-EPMC6498752 | biostudies-literature
GenomicsApolipoprotein E4 Is Associated with a Distinct Transcriptomic Profile of Hippocampal Neurons and Attenuates Their Maturation In Vitro
Apolipoprotein E4 Is Associated with a Distinct Transcriptomic Profile of Hippocampal Neurons and Attenuates Their Maturation In Vitro
PRJNA795162 | ENA
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