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TranscriptomicsThe Ink4a/Arf locus operates as a regulator of the circadian clock modulating RAS activity
Upon perturbations by RAS and by shBMAL, differential effects on the circadian phenotype were observed in wild type and Ink4a/Arf knockout MEFs which could be reproduced by modelling simulations and correlated with opposing cell cycle fate decisions.
ORGANISM(S): Mus musculus 
2017-12-08 | E-MTAB-5943 | biostudies-arrayexpress
TranscriptomicsArf Tumor Suppressor and miR-205 Regulate Cell Adhesion and Formation of Extraembryonic Endoderm from Pluripotent Stem Cells
Induction of the Arf tumor suppressor in response to hyperproliferative stress following oncogene activation activates a p53-dependent transcriptional program that limits the expansion of incipient cancer cells. Although Arf is not expressed in most tissues of fetal or young adult mice, it is physi...
ORGANISM(S): Mus musculus 
2013-04-01 | E-GEOD-42210 | biostudies-arrayexpress
TranscriptomicsReal-time quantitative PCR analysis of ARF-deficient macrophages
Macrophages are a major cellular component of all inflammatory situations, generating proinflammatory cytokines such as TNF-alpha, IL-1, and IL-6 that are central to the initiation and maintenance of inflammation. To determine whether the tumor suppressor ARF plays a role in inflammatory gene expres...
ORGANISM(S): Mus musculus 
2011-09-29 | E-GEOD-32446 | biostudies-arrayexpress
TranscriptomicsGene expression in rat kidney following recovery from acute renal failure (ARF)
This experiment was designed to study the alteration in expression of mRNA is kidney following recovery from transient acute renal failure. The model used was a 52 min. bilateral renal artery clamping, followed by reperfusion, which resulted in a transient loss of renal function, followed by a func...
ORGANISM(S): Rattus norvegicus 
2010-06-10 | E-GEOD-1714 | biostudies-arrayexpress
TranscriptomicsEffect of ARF on the transcription of p53 target genes in homologous recombination deficient cells
ARF is a tumour suppressor activated by oncogenic stress, which stabilizes p53. Although p53 is a key component of the response to DNA damage, a similar function for ARF has not been ascribed. In this work we show that homologous recombination (HR) -deficient primary mouse and human cells accumulate...
ORGANISM(S): Mus musculus 
2014-12-04 | E-GEOD-51354 | biostudies-arrayexpress
ProteomicsProximal interaction network of ARF GTPases
The Arf GTPase family is involved in a wide range of cellular regulation including membrane trafficking and organelle structure assembly. Here, we have generated a proximity interaction network for the Arf family using the miniTurboID approach combined with TMT-based quantitative mass spectrometry. ...
ORGANISM(S): Homo sapiens (Human) 
2022-07-20 | PXD033382 | Pride
Arf gtpases Tmt Proximal labeling Ms 
TranscriptomicsTranscription profiling of mouse Bmi1-overexpressing Ink4a-Arf-null hepatoblasts
Forced expression of Bmi1 accelerated the self-renewal of hepatic stem/progenitor cells and eventually induced their transformation in an in vivo transplant model. The Ink4a/Arf locus, which encodes a cyclin-dependent kinase inhibitor, p16Ink4a, and a tumor suppressor, p19Arf, is a pivotal target of...
ORGANISM(S): Mus musculus 
2009-08-07 | E-GEOD-17462 | biostudies-arrayexpress
ProteomicsArabidopsis ARF-ARFGEF interaction analyzed by AP-MS
In Arabidopsis and presumably other flowering plant species as well, there are two non-conserved putative ARF GTPases in addition to the eukaryotically conserved ARF1 (class I) and eight ARF guanine-nucleotide exchange factors (ARF-GEFs) that appear to be involved in specific membrane-trafficking pa...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2018-11-07 | PXD011594 | Pride
Arf-gefs Arabidopsis Arf gtpases Membrane traffic 
TranscriptomicsTranscription profiling of mouse neural stem cells derived from Ink4a/Arf-/- vs Bmi1-/-;Ink4a/Arf-/- mutants
Comparison of gene expression of Ink4a/Arf-/- vs Bmi1-/-;Ink4a/Arf-/- subventricular zone (SVZ) derived mouse neural stem cells (NSC) on Laminin (LM) and Fibronectin (FN) substrates.
ORGANISM(S): Mus musculus 
2009-02-25 | E-NCMF-22 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of pre-injected brain cells from female INK4a/ARF knock-out, BMI1 INK4a/ARF knock-out mice and tumor cells derived from these mice
Comparison of gene expression profiles between pre-injected brain cells from female INK4a/ARF knock-out, BMI1 INK4a/ARF knock-out mice and tumor cells derived thereof.
ORGANISM(S): Mus musculus 
2007-11-15 | E-NCMF-4 | biostudies-arrayexpress
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