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ProteomicsRUFY3 links Arl8b and JIP4-Dynein complex to regulate lysosome size and positioning
The whole-cell scale spatial organization of lysosomes is regulated by their bidirectional motility on microtubule tracks. Small GTP-binding (G) protein, Arl8b, stimulates the anterograde transport of lysosomes by recruiting adaptor protein SKIP (also known as PLEKHM2), which in turn couples the mic...
ORGANISM(S): Homo sapiens (Human) 
2022-03-23 | PXD027010 | Pride
Arl8b Lysosome Small gtpase Dynein Microtubule 
UnknownARL8B regulates lysosomal function and predicts poor prognosis in hepatocellular carcinoma.
Not available
S-EPMC11985964 | biostudies-literature
UnknownThe Rab7 effector PLEKHM1 binds Arl8b to promote cargo traffic to lysosomes.
Not available
S-EPMC5379943 | biostudies-literature
UnknownThe small GTPase Arl8b regulates assembly of the mammalian HOPS complex on lysosomes.
Not available
S-EPMC4432227 | biostudies-literature
UnknownRUFY3 links Arl8b and JIP4-Dynein complex to regulate lysosome size and positioning.
Not available
S-EPMC8938454 | biostudies-literature
UnknownVPS41 recruits biosynthetic LAMP-positive vesicles through interaction with Arl8b.
Not available
S-EPMC11809577 | biostudies-literature
UnknownLysosomal trafficking mediated by Arl8b and BORC promotes invasion of cancer cells that survive radiation.
Not available
S-EPMC7591908 | biostudies-literature
UnknownSKIP-HOPS recruits TBC1D15 for a Rab7-to-Arl8b identity switch to control late endosome transport.
Not available
S-EPMC7073467 | biostudies-literature
UnknownRUFY1 binds Arl8b and mediates endosome-to-TGN CI-M6PR retrieval for cargo sorting to lysosomes.
Not available
S-EPMC9597352 | biostudies-literature
UnknownDENND6A links Arl8b to a Rab34/RILP/dynein complex, regulating lysosomal positioning and autophagy.
Not available
S-EPMC10830484 | biostudies-literature
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