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TranscriptomicsWide-scale transcriptome disturbance underlies liver and kidney pathology from chronic ultra low dose Roundup exposure
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Rattus norvegicus 
2015-09-04 | E-GEOD-66060 | biostudies-arrayexpress
TranscriptomicsDistinct Micro-RNA profiles are associated with severity of hepatitis C virus recurrence and acute cellular rejection after liver transplant
Recurrent hepatitis C virus (rHCV) is universal post-liver transplantation (LT), with accelerated fibrosis rates compared to non-transplanted patients. rHCV is associated with increased mortality and morbidity post-transplant and is a leading indication for re-transplantation. We hypothesized that m...
ORGANISM(S): Homo sapiens 
2013-09-17 | E-GEOD-40113 | biostudies-arrayexpress
TranscriptomicsThe influence of folate supplementation on global gene expression in normal colonic mucosa of subjects with colorectal adenoma
Background: We tested the hypothesis that short-term supplementation with a physiological dose of folate can alter global gene expression in the colon of subjects with colorectal adenoma using a randomised double blind placebo controlled trial design. Materials and Methods: Fourteen subjects with h...
ORGANISM(S): Homo sapiens 
2013-10-01 | E-GEOD-40928 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis reveals differential effects of conjugated linoleic acid isomers in ritonavir-treated 3T3-L1 adipocytes
Objective: To quantify changes in adipogenic gene expression in the presence of ritonavir (RTV) or tenofovir (TDF), and determine whether conjugated linoleic acid (CLA) isomers (cis9,trans11 or trans10,cis12) can mitigate detrimental effects of antiretoviral drugs. Methods: Affymetrix Mouse Genome 4...
ORGANISM(S): Mus musculus 
2016-07-07 | E-GEOD-70854 | biostudies-arrayexpress
TranscriptomicsBrewer - M.muscuclus - NOX4 TG
Transcriptomic analysis of cardiomyocytes in NOX4 transgenic mice
ORGANISM(S): Mus musculus 
2014-06-01 | E-MEXP-3161 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of GATA-6 overexpression in mouse P19CL6 cells to identify targets of GATA-6 transcriptional regulation at early stages of cardiogenesis
effect of overexpression of GATA-6 in P19 CL6 induced cells
ORGANISM(S): Mus musculus 
2007-01-10 | E-MEXP-628 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Xenopus dorsal root ganglia conditioned in vitro vs freshly dissected control
Axonal regeneration is enhanced by prior conditioning peripheral nerve lesions. Here we show that Xenopus dorsal root ganglia (DRGs) with attached peripheral nerves (PN-DRGs) can be conditioned in vitro, thereafter showing enhanced axonal growth in response to neurotrophins, similar to preparations...
ORGANISM(S): Xenopus laevis 
2008-04-16 | E-MEXP-1297 | biostudies-arrayexpress
TranscriptomicsExpression profiling of palatal shelves in Tbx1 mutant mice
To assess the influence of Tbx1 on gene expression profile within the developing palate we performed a microarray screen using RNA isolated from dissected secondary palate shelves of E13.5 wild type, Tbx1+/- and Tbx1-/- mice. Significant differences were identified between genotypes, with a total of...
ORGANISM(S): Mus musculus 
2013-04-02 | E-GEOD-37904 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression to VEGF in aorta from wild-type and C42S PKARI knock-in mice
Angiogenesis is essential for tissue development, wound healing and tissue perfusion, with its dysregulation linked-to tumorigenesis, rheumatoid arthritis and heart disease. Here we show pro-angiogenic stimuli couple to NADPH oxidase-dependent generation of oxidants that catalyse an activating inter...
ORGANISM(S): Mus musculus 
2015-06-24 | E-GEOD-70216 | biostudies-arrayexpress
TranscriptomicsRetinoic acid signaling constrains the plasticity of Th1 cells and prevents development of pathogenic Th17 cells [Affymetrix experiments]
CD4+ T cells differentiate into phenotypically distinct T-helper cells upon antigenic stimulation. Regulation of plasticity between these CD4+ T-cell lineages is critical for immune homeostasis and prevention of autoimmune diseases. However, the factors that regulate lineage stability are largely un...
ORGANISM(S): Mus musculus 
2015-03-10 | E-GEOD-60354 | biostudies-arrayexpress
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