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TranscriptomicsOverexpression of c-Jun in mouse Schwann cells of uninjured nerves
Two mouse lines, OE/+ and OE/OE were generated expressing graded elevation (6 fold and 28 fold, respectively) of c-Jun protein selectively in Schwann cells. The effects of this on global gene expression and cellular structure in uninjured nerves was analysed during development and in the adult. Chan...
ORGANISM(S): Mus musculus 
2017-10-16 | E-MTAB-6138 | biostudies-arrayexpress
TranscriptomicsFailures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun
After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during the chronic denervation that results from slow axon growth. This impairs axonal regeneration and ca...
ORGANISM(S): Mus musculus 
2020-10-14 | E-MTAB-9640 | biostudies-arrayexpress
UnknownCPX-351 (cytarabine and daunorubicin) Liposome for Injection Versus Conventional Cytarabine Plus Daunorubicin in Older Patients With Newly Diagnosed Secondary Acute Myeloid Leukemia.
Not available
S-EPMC6127025 | biostudies-literature
ProteomicsProteomics of Day 6 IL-2 or IL-15 expanded wild-type and Pim1/Pim2 double knockout CD8+ T cells.
T cell antigen-receptor (TCR) and cytokine receptor engagement trigger large changes in Serine/Threonine kinase signalling networks to drive T cell activation and differentiation. The role of only few kinase signalling pathways have been studied in detail, and in this context, Pim kinases are an int...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-15 | PXD051213 | Pride
Lc-msms Mouse Pim1 Pim2 Cytotoxic t lymphocyte Pim kinase Il-2 Il-15 
TranscriptomicsSubtypes of HPV-positive head and neck cancers are associated with HPV characteristics, copy number variations, PIK3CA mutation, and pathway signatures. [RNA-Seq]
Purpose: There is substantial heterogeneity within the human papillomavirus (HPV) positive head and neck cancer (HNC) tumors that predispose them to different outcomes, however this subgroup is poorly characterized due to various historical reasons. Experimental Design: we perform unsupervised gene...
ORGANISM(S): Homo sapiens 
2016-05-13 | E-GEOD-74927 | biostudies-arrayexpress
ProteomicsCOQ4 Affinity Enrichment Mass Spectrometry
Affinity enrichment mass spectrometry experiment to identify protein-protein interactions of hCOQ4-FLAG WT and hCOQ4-FLAG D164A.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-10-26 | MSV000093201 | MassIVE
UnknownImpact of centre volume, surgeon volume, surgeon experience and geographic location on reoperation after intramedullary nailing of tibial shaft fractures
Not available
S-EPMC8410470 | biostudies-literature
ModelsCardiomyocyte Telomere Damage
No description
2019-02-14 | MODEL1608250000 | BioModels
ModelsCardiomyocyte Telomere Damage by ROS without Cell Division
No description
2019-02-14 | MODEL1608250001 | BioModels
UnknownEffects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer's disease: a randomized, controlled clinical trial.
Not available
S-EPMC11157928 | biostudies-literature
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