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ProteomicsAnalysis of cryopreservation of human granulosa cells
Human primary granulosa cells (GCs) derived from women, undergoing oocyte retrieval, can be cultured and are a cellular model for the study of human ovarian functions. In vitro they change rapidly, resembling initially cells of the preovulatory follicle and then cells of the corpus luteum. They are ...
ORGANISM(S): Homo sapiens (Human) 
2021-07-28 | PXD025632 | Pride
Mass spectrometry Ivf Cell culture Progesterone Ovarian cells Cryopreservation 
ProteomicsMitochondrial dynamics in ovarian granulosa cells during follicular growth and in human KGN cells
In the ovary, proliferation and differentiation of granulosa cells (GCs) drive the growth of follicles. This is, in part, dependent on gonadotropins. Our immunohistochemical studies provided hints of mitochondrial biogenesis and intracellular redistribution in GCs of growing follicles. A cellular mo...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD032160 | Pride
Mitochondrial dynamics Ovary Forskolin Camp Kgn Granulosa cells 
ProteomicsThe impact of hypoxia on KGN cells
Human granulosa cells (GCs) give rise to granulosa cell tumors (GCTs), in which a hypoxic situation can be assumed. KGN cells are a widely used cellular model for both tumorous and normal human GCs. In this study, we evaluated consequences of hypoxic (1% O2) versus atmospheric conditions on KGNs for...
ORGANISM(S): Homo sapiens (Human) 
2025-11-19 | PXD056016 | Pride
Proteomics Hypoxia Granulosa cell tumor 
ProteomicsRegulation of human granulosa cells by oxygen
Human granulosa cells (GCs), obtained during medical reproductive procedures can be cultured and are a cellular model for the human ovary. Oxygen concentrations are regarded as important regulators of GCs. We examined consequences of low (1%) O2 versus standard atmospheric conditions in cultured hum...
ORGANISM(S): Homo sapiens (Human) 
2023-12-20 | PXD042934 | Pride
Ovary Proteomic analysis Inflammation Hypoxia 
ProteomicsPumillio-Pumillio-2 is involved in the regulation of human ovarian granulosa tumor cells2 is involved in the regulation of human ovarian granulosa tumor cells
The RNA-binding protein Pumillio-2 (encoded by PUM2) is active during embryonic development and cell differentiation, but possible roles in the dynamic human ovary or in ovarian granulosa cell (GC)-derived tumors, were not known. We studied KGN cells, which are derived from a human GC tumor. We empl...
ORGANISM(S): Homo sapiens (Human) 
2026-07-02 | PXD064140 | Pride
Human ovary Rna-binding protein Granulosa tumor cells Proliferation 
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