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ProteomicsSILAC analysis of the effects of AS1411 on 3T3 cell proteome.
Here we conducted a SILAC analysis to study the effects of AS1411 on 3T3 cell proteome, and found that AS1411 consistently downregulated the expression of cholesterol biosynthesis enzymes
ORGANISM(S): Mus musculus (Mouse) 
2025-10-17 | PXD055162 | Pride
Cholesterol biosynthesis pathway Nucleolin As1411 Aptamer 
GenomicsEffect of nucleolin-binding aptamer AS1411 on gene expression in 3T3 cells
Effect of nucleolin-binding aptamer AS1411 on gene expression in 3T3 cells
PRJNA1147748 | ENA
TranscriptomicsEffect of nucleolin-binding aptamer AS1411 on gene expression in 3T3 cells
AS1411 is a G-rich DNA aptamer that targets the multifunctional RNA-binding protein nucleolin. AS1411 has both antiproliferative and cell size-regulating activities and has been evaluated for clinical utility, reaching phase II trials as an anticancer agent. The mechanisms underlying the different a...
ORGANISM(S): Mus musculus 
2025-10-27 | GSE274745 | GEO
UnknownAnti-nucleolin aptamer AS1411: an advancing therapeutic.
Not available
S-EPMC10551449 | biostudies-literature
UnknownBioactivity of 2'-deoxyinosine-incorporated aptamer AS1411.
Not available
S-EPMC4872150 | biostudies-literature
UnknownExploring the G-Quadruplex Formation of AS1411 Derivatives.
Not available
S-EPMC12029569 | biostudies-literature
UnknownInsights into the binding mode of AS1411 aptamer to nucleolin.
Not available
S-EPMC9574071 | biostudies-literature
UnknownLocking up the AS1411 Aptamer with a Flanking Duplex: Towards an Improved Nucleolin-Targeting.
Not available
S-EPMC7916057 | biostudies-literature
UnknownMechanistic studies of anticancer aptamer AS1411 reveal a novel role for nucleolin in regulating Rac1 activation.
Not available
S-EPMC4523413 | biostudies-literature
UnknownToward G-Quadruplex-Based Anticancer Agents: Biophysical and Biological Studies of Novel AS1411 Derivatives.
Not available
S-EPMC7590035 | biostudies-literature
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