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MetabolomicsMyeloid PFKFB3-mediated glycolysis promotes kidney fibrosis
Excessive renal fibrosis is a common pathology in progressive chronic kidney diseases. Inflammatory injury and aberrant repair processes contribute to the development of kidney fibrosis. Myeloid cells, particularly monocytes/macrophages, play a crucial role in kidney fibrosis by releasing their proi...
2024-03-12 | MTBLS8278 | MetaboLights
ProteomicsSerial-Omics of Equine Urine - Serial-omics characterization of equine urine
Horse urine is easily collected and contains molecules readily measurable using mass spectrometry that can be used as biomarkers representative of health, disease or drug tampering. This study aimed at analyzing microliter levels of horse urine to purify, identify and quantify proteins, polar metabo...
ORGANISM(S): Equus caballus (Horse) 
2018-07-23 | PXD007646 | Pride
Metabolomics Equine Lipidomics Horse Proteomics Urine Integration Biomarkers 
ProteomicsAncient fossil sequencing - Interpreting sequences from mastodon and T
Not available
ORGANISM(S): Tyrannosaurus rex (Tyrant lizard king) Dinosauria 
2009-07-09 | PRD000074 | Pride
ProteomicsFossil bone sequencing - Protein sequences from mastodon and Tyrannosaurus rex revealed by mass spectrometry
Not available
ORGANISM(S): Struthio camelus (Ostrich) 
2009-07-28 | PRD000085 | Pride
ProteomicsAncient fossil bone sequencing
Not available
ORGANISM(S): Mammut americanum (American mastodon) 
2009-07-28 | PRD000088 | Pride
ProteomicsProteomic characterization of human multiple myeloma bone marrow
Glavey SV, Naba A, Manier S, Clauser KR, Tahri S, Park J, Reagan MR, Moschetta M, Mishima Y, Gambella M, Rocci A, Sacco A, Asara JM, Palumbo A, Roccaro AM, Hynes RO, Ghobrial IM. The extracellular matrix (ECM) is a major component of the tumor microenvironment, contributing to the regulation of cell...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-01-06 | MSV000080451 | MassIVE
MetabolomicsPFKFB3-mediated glycolysis boosts fibroblast activation and subsequent kidney fibrosis

Renal fibrosis, a hallmark of chronic kidney diseases, is driven by the activation of renal fibroblasts. Recent studies have highlighted the role of glycolysis in this process. Nevertheless, one critical glycolytic activator, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3), remain...

2024-03-12 | MTBLS8281 | MetaboLights
MetabolomicsClock regulation of metabolites reveals coupling between transcription and metabolism
The circadian clock is intricately connected with metabolism, however the precise details of these connections are incomplete. Here we used high temporal resolution metabolite profiling to determine circadian regulation of mouse liver and cell autonomous metabolism. In mouse liver, we found ~50% of ...
2017-04-05 | MTBLS292 | MetaboLights
ProteomicsMultiplexed proteomics of a cellular transition from G0 to cell cycle in response to IL-3 activation
There exist similarities and differences in metabolism and physiology between normal proliferative cells and tumor cells. Once a cell enters the cell cycle, metabolic machinery is engaged to facilitate various processes. The kinetics and regulation of these metabolic changes have not been properly e...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2017-06-21 | MSV000081179 | MassIVE
UnknownTransaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma.
Not available
S-EPMC6219629 | biostudies-literature
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