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TranscriptomicsTranscription profiling of mouse intestinal cells expressing Lgr5 at high or low levels or with Ascl2 conditionally knocked out shows Ascl2 controls intestinal stem cell fate
The small intestinal epithelium is the most rapidly self-renewing tissue of mammals. Proliferative cells are confined to crypts, while differentiated cell types predominantly occupy the villi. We recently demonstrated the existence of a long-lived pool of cycling stem cells defined by Lgr5 expressio...
ORGANISM(S): Mus musculus 
2009-03-25 | E-GEOD-14201 | biostudies-arrayexpress
GenomicsAscl2 acts as an R-spondin/Wnt responsive switch to control stemness in intestinal crypts [ChIP-seq]
Wnt signals control three functions of intestinal crypts: maintenance of Lgr5 stem cells, proliferation of transit-amplifying daughters and formation of Paneth cells. Here, we study how the Wnt effector β-catenin/Tcf4 cooperates with the Wnt-activated transcription factor Ascl2 to control a stem ce...
ORGANISM(S): Homo sapiens 
2016-07-15 | E-GEOD-84456 | biostudies-arrayexpress
ProteomicsASCL2 is a key regulator of the proliferation-differentiation equilibrium in the esophageal epithelium
The esophagus is protected from the hostile environment by a stratified epithelium, which renews rapidly. Homeostasis of this epithelium is ensured by a rare population of stem cells in the basal layer: Keratin 15+ (Krt15+) cells. However, little is known about the molecular mechanisms regulating th...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-24 | PXD039477 | Pride
Esophagus Differentiation Stem cells Ascl2 Proliferation 
GenomicsTranscription factor Achaete-Scute homologue 2 initiates T follicular helper cell development [ChIP-Seq]
In immune responses, activated T cells migrate to B cell follicles and develop to T follicular helper (Tfh) cells, a new subset of CD4+ T cells specialized in providing help to B lymphocytes in the induction of germinal centers 1-3. Although Bcl6 has been shown to be essential in Tfh cell function, ...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-52839 | biostudies-arrayexpress
TranscriptomicsHuman colon cancer HT-29 and LS174T cells: stably transfected with shRNA-Ascl2/EGFP vs. stably transfected with shRNA-Control/EGFP
Achaete scute-like 2 (Ascl2), a basic helix-loop-helix (bHLH) transcription factor, controls the fate of intestinal stem cells. However, the role of Ascl2 in colon cancer progenitor cells remains unknown. The cell lines HT-29 (47.5-95% of CD133+ population) and LS174T (0.45% of CD133+ population) we...
ORGANISM(S): Homo sapiens 
2012-01-07 | E-GEOD-34926 | biostudies-arrayexpress
ProteomicsSpecific labeling of stem cell activity in human colorectal organoidsusing an ASCL2-responsive minigene
Organoid technology provides the possibility to culture human colontissue and patient-derived colorectal cancers (CRC) while maintainingall functional and phenotypic characteristics. Labeling of human colonstem cells (CoSCs), especially in normal and benign tumor organoids, ischallenging and therefo...
ORGANISM(S): Homo sapiens (Human) 
2018-01-29 | PXD006575 | Pride
Intestine Ascl2 Organoids Stem cells Lgr5 Colorectal cancer 
GenomicsASCL2 drives sorafenib resistance through FSAN-mediated MDR1 palmitoylation
ASCL2 drives sorafenib resistance through FSAN-mediated MDR1 palmitoylation
PRJNA1447465 | ENA
GenomicsAscl2-dependent cell differentiation drives regeneration of abated intestinal stem cells
Ascl2-dependent cell differentiation drives regeneration of abated intestinal stem cells
PRJNA541521 | ENA
GenomicsASCL2 reciprocally controls key trophoblast lineage decisions during hemochorial placenta development
ASCL2 reciprocally controls key trophoblast lineage decisions during hemochorial placenta development
PRJNA645927 | ENA
GenomicsTranscription factor Ascl2 promotes geminal center B cell responses through directly regulating AID transcription
Transcription factor Ascl2 promotes geminal center B cell responses through directly regulating AID transcription
PRJNA716539 | ENA
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