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Symbiotic microorganisms play an important role in the growth and development of marine invertebrates, such as the sea moon, affecting their metamorphosis process. The outbreak of jellyfish puts pressure on marine ecosystems and affects their stability. However, researches on the development of j...

2024-06-03 | MTBLS9419 | MetaboLights

Symbiotic microorganisms play an important role in the growth and development of marine invertebrates, such as the sea moon, affecting their metamorphosis process. The outbreak of jellyfish puts pressure on marine ecosystems and affects their stability. However, researches on the development of j...

2024-06-03 | MTBLS9409 | MetaboLights
For malaria transmission, the parasite must undergo sexual differentiation into mature gametocytes. However, the molecular basis for this critical transition in the parasites life cycle is unknown. Six previously uncharacterized genes, Pfg14.744, Pfg14.745, Pfg14.748, Pfg14.763, Pfg14.752 and Pfg6.6...
ORGANISM(S): Plasmodium falciparum 
Prediction of the antimalarial potential of small molecules using data from various chemical libraries that were screened against the asexual and sexual (gametocyte) stages of the parasite. Several compounds’ molecular fingerprints were used to train machine learning models to recognize stage-specif...
2024-03-28 | MODEL2403270002 | BioModels
PfSRPK1 regulates asexual blood stage schizogony and is essential for male gamete formation
Here, we characterized an RNA binding protein (RBP), PfDOZI, which is an integral cytoplasmic component of RNP granule. We observed that deleting pfdozi led to an asexual growth advantage due to the escalated merozoite invasion capacity. Also, pfdozi disruption resulted in a significant impairment i...
ORGANISM(S): Plasmodium falciparum 
2024-04-16 | PXD020862 | Pride
An ApiAP2 transcription factor modulates stage-specific gene expression and asexual development in Eimeria tenella
The transcriptome of the planarian Schmidtea mediterranea is not well characterized. We have used RNA-Seq to characterize the transcriptome in both sexual and asexual strains of S. mediterranea from both untreated and irradiated animals. Moreover, we have performed RNA-Seq on RNA purified from FAC...
ORGANISM(S): Schmidtea mediterranea 
Serine/arginine-rich protein kinases (SRPK) are cell cycle-regulated serine/threonine protein kinases and are important regulators of splicing factors. In this study, we functionally characterize SRPK1 of the human malaria parasite Plasmodium falciparum (Pf). PfSRPK1 was expressed in asexual blood s...
ORGANISM(S): Plasmodium falciparum 
2022-08-29 | GSE212142 | GEO
Ring-infected erythrocytes are the predominant asexual stage in the peripheral circulation but are rarely investigated in the context of acquired immunity against Plasmodium falciparum malaria. Here we compare antibody-dependent phagocytosis of ring-infected parasite cultures in samples from a contr...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2022-08-11 | PXD033964 | Pride
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