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ProteomicsCell-matrix adhesion contributes to permeability control in human colon organoids
Background and aims: Cell-cell adhesion structures (desmosomes and, especially, tight junctions) are known to play important roles in control of transepithelial permeability in the colon. The involvement of cell-matrix interactions in permeability control is less clear. The goals of the present stud...
ORGANISM(S): Homo sapiens (Human) 
2022-03-14 | PXD026923 | Pride
Colon organoids Basement membrane Gut barrier Colon Intestinal permeabilty 
ProteomicsLiver Proteomic Profile in Mice on a High-Fat Diet
Nonalcoholic fatty liver disease (NAFLD) is becoming a primary cause of liver damage in Western society. Nonalcoholic steatohepatitis (NASH) is an advanced stage of NAFLD and may lead to liver cancer. Our previous long-term murine studies have shown the beneficial role of Aquamin, a red marine algae...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-02 | PXD030954 | Pride
Ccn3 High fat Liver cancer Minerals Nash Nafld 
ProteomicsProteomic Profile of Human Colon Organoids: Effects of a multi-mineral intervention alone and in the presence of pro-Inflammatory and anti-inflammatory treatments
Introduction: Aquamin, a multi-mineral product derived from fossilized red marine algae, has been shown to improve colon barrier structure and function. Mesalamine is commonly used as maintenance therapy for patients with mild-to-moderate ulcerative colitis (UC) or those in remission. Our long-term ...
ORGANISM(S): Homo sapiens (Human) 
2026-03-16 | PXD062086 | Pride
Ulcerative colitis Gut barrier Mesalamine Inflammation Aquamin Colon organoids 
ProteomicsA Multi-Mineral Intervention to Modulate Colonic Mucosal Protein Profile: Results from a 90-Day Trial in Human Subjects
The overall goal of this study was to determine if Aquamin®, a multi-mineral natural product, would alter the expression of proteins involved in growth-regulation and differentiation in the colon. Thirty healthy human subjects (at risk for colorectal cancer) were enrolled in a three-arm, 90-day inte...
ORGANISM(S): Homo sapiens (Human) 
2021-03-19 | PXD024445 | Pride
Aquamin  biomarkers  calcium  colon cancer chemoprevention  minerals  proteomic analysis  trace elements 
ProteomicsUlcerative Colitis-Derived Colonoid Culture: 2 A multi-mineral-approach to improve barrier protein expression
Background. Recent studies demonstrated that Aquamin®, a calcium-, magnesium-, and multiple trace element-rich natural product, improves barrier structure and function in colonoids obtained from the tissue of healthy subjects. The goal of the present study was to determine if the colonic barrier co...
ORGANISM(S): Homo sapiens (Human) 
2020-12-17 | PXD020244 | Pride
Basement membrane Desmosome Calcium Colonoid Cell barrier 29 proteomics Ulcerative colitis 
UnknownAssociation of a high-fat diet with I-FABP as a biomarker of intestinal barrier dysfunction driven by metabolic changes in Wistar rats.
Not available
S-EPMC10223920 | biostudies-literature
UnknownProphylactic potential of honey and Nigella sativa L. against hospital and community-based SARS-CoV-2 spread: a structured summary of a study protocol for a randomised controlled trial.
Not available
S-EPMC8441040 | biostudies-literature
UnknownEvaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries.
Not available
S-EPMC10771257 | biostudies-literature
UnknownEmpagliflozin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC10957483 | biostudies-literature
UnknownHigher dose corticosteroids in hospitalised COVID-19 patients requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC11872607 | biostudies-literature
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