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ProteomicsIdentification of inhibitors for the trans-membrane Trypanosoma cruzi eIF2alpha kinase relevant for parasite proliferation
We studied the impact of the gene knockout of the TcK2 protein kinase of Trypanosoma cruzi, the causative agent of Chagas disease. TcK2 is structurally similar to the human kinase PERK, which phosphorylates the initiation factor eIF2alpha, and in turn, inhibits translation initiation. As TcK2 kinase...
ORGANISM(S): Trypanosoma cruzi 
2023-07-20 | PXD040597 | Pride
Chemical inhibitor Recombinant protein T. cruzi eif2ak2 Protein kinase Chagas disease Invasion Proteome Assay eif2alpha 
TranscriptomicsTranscription profiling of mouse Perk wild-type and knockout liver perfused without or with 2,5-di-tert-butylhydroquinone
In eukaryotes, regulation of mRNA translation enables a fast, localized and finely tuned expression of gene products. Within the translation process, the first stage of translation initiation is most rigorously modulated by the actions of eukaryotic initiation factors (eIFs) and their associated pr...
ORGANISM(S): Mus musculus 
2009-11-23 | E-GEOD-11684 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Gcn2 wild-type and knockout liver perfused with or without methionine
In eukaryotes, regulation of mRNA translation enables a fast, localized and finely tuned expression of gene products. Within the translation process, the first stage of translation initiation is most rigorously modulated by the actions of eukaryotic initiation factors (eIFs) and their associated pr...
ORGANISM(S): Mus musculus 
2009-11-23 | E-GEOD-11496 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver to assess the translational response following activation of GCN2 versus PERK - super series
In eukaryotes, regulation of mRNA translation enables a fast, localized and finely tuned expression of gene products. Within the translation process, the first stage of translation initiation is most rigorously modulated by the actions of eukaryotic initiation factors (eIFs) and their associated pr...
ORGANISM(S): Mus musculus 
2009-11-23 | E-GEOD-11685 | biostudies-arrayexpress
UnknownProtein kinase PKR mutants resistant to the poxvirus pseudosubstrate K3L protein.
Not available
S-EPMC2579349 | biostudies-literature
UnknownHepatitis C virus controls interferon production through PKR activation.
Not available
S-EPMC2868028 | biostudies-literature
TranscriptomicsTranscription profiling of human Hela cells infected with Vaccinia mutants
Samples were received from the lab of Bertram Jacobs, experiments done by Jeff Langland (langland@asu.edu). Midlog Hela cells were infected with copenhagen strain Vaccinia Virus at MOI of 5. Viral stocks were sucrose pad purified. Incubated 2, 6, and 9 hrs post infection. viral mutants include VC2 (...
ORGANISM(S): Homo sapiens 
2007-04-01 | E-TABM-64 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse embryonic fibroblasts (MEF) from wild type vs CHOP-/- genotypes treated with tunicamycin reveals CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum
Primary mouse embryonic fibroblasts (pass 3 to 4) were treated with tunicamycin (2 micrograms/ml) for specified times - genotypes were WILDTYPE and CHOP-/-. Each time point n=4. C/EBP homologous protein CHOP is activated by ER stress, and CHOP deletion protects against its lethal consequences.
ORGANISM(S): Mus musculus 
2007-12-11 | E-GEOD-2082 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human lung carcinome calls treated WITH Farnesol reveals Farnesol-induced apoptosis IS coupled TO THE endoplasmic reticulum (ER) stress response
Farnesol (FOH) and other isoprenoid alcohols induce apoptosis in various carcinoma cells and inhibit tumorigenesis in several in vivo models. However, the mechanisms by which these isoprenoids mediate their effects are not yet fully understood. In this study, we show that FOH is effective inducer of...
ORGANISM(S): Mus musculus 
2008-04-07 | E-GEOD-7215 | biostudies-arrayexpress
UnknownIsolation of Flavonoids from Deguelia duckeana and Their Effect on Cellular Viability, AMPK, eEF2, eIF2 and eIF4E.
Not available
S-EPMC6274060 | biostudies-literature
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